Deregulated NF-κB activity in haematological malignancies

被引：49

作者：

Keutgens, Aurore ^{[1
]}

Robert, Isabelle ^{[1
]}

Viatour, Patrick ^{[1
]}

Chariot, Alain ^{[1
]}

机构：

[1] Univ Liege, Ctr Biomed Integrat Genoproteom, Ctr Cellular & Mol Therapy, Med Chem Lab,CHU Sart Tilman, B-4000 Liege, Belgium

来源：

BIOCHEMICAL PHARMACOLOGY | 2006年 / 72卷 / 09期

关键词：

NF-kappa B; I kappa B; IKK; p100; BCL-3; lymphoma; leukemia; Hodgkin disease;

D O I：

10.1016/j.bcp.2006.06.011

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The NF-kappa B family of transcription factors plays key roles in the control of cell proliferation and apoptosis. Constitutive NF-kappa B activation is a common feature for most haematological malignancies and is therefore believed to be a crucial event for enhanced proliferation and survival of these malignant cells. In this review, we will describe the molecular mechanisms underlying NF-kappa B deregulation in haematological malignancies and will highlight what is still unclear in this field, 20 years after the discovery of this transcription factor. (c) 2006 Elsevier Inc. All rights reserved.

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页码：1069 / 1080

页数：12

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