Deregulated NF-κB activity in haematological malignancies

被引：49

作者：

Keutgens, Aurore ^{[1
]}

Robert, Isabelle ^{[1
]}

Viatour, Patrick ^{[1
]}

Chariot, Alain ^{[1
]}

机构：

[1] Univ Liege, Ctr Biomed Integrat Genoproteom, Ctr Cellular & Mol Therapy, Med Chem Lab,CHU Sart Tilman, B-4000 Liege, Belgium

来源：

BIOCHEMICAL PHARMACOLOGY | 2006年 / 72卷 / 09期

关键词：

NF-kappa B; I kappa B; IKK; p100; BCL-3; lymphoma; leukemia; Hodgkin disease;

D O I：

10.1016/j.bcp.2006.06.011

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The NF-kappa B family of transcription factors plays key roles in the control of cell proliferation and apoptosis. Constitutive NF-kappa B activation is a common feature for most haematological malignancies and is therefore believed to be a crucial event for enhanced proliferation and survival of these malignant cells. In this review, we will describe the molecular mechanisms underlying NF-kappa B deregulation in haematological malignancies and will highlight what is still unclear in this field, 20 years after the discovery of this transcription factor. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：1069 / 1080

页数：12