Deregulated NF-κB activity in haematological malignancies

被引：49

作者：

Keutgens, Aurore ^{[1
]}

Robert, Isabelle ^{[1
]}

Viatour, Patrick ^{[1
]}

Chariot, Alain ^{[1
]}

机构：

[1] Univ Liege, Ctr Biomed Integrat Genoproteom, Ctr Cellular & Mol Therapy, Med Chem Lab,CHU Sart Tilman, B-4000 Liege, Belgium

来源：

BIOCHEMICAL PHARMACOLOGY | 2006年 / 72卷 / 09期

关键词：

NF-kappa B; I kappa B; IKK; p100; BCL-3; lymphoma; leukemia; Hodgkin disease;

D O I：

10.1016/j.bcp.2006.06.011

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The NF-kappa B family of transcription factors plays key roles in the control of cell proliferation and apoptosis. Constitutive NF-kappa B activation is a common feature for most haematological malignancies and is therefore believed to be a crucial event for enhanced proliferation and survival of these malignant cells. In this review, we will describe the molecular mechanisms underlying NF-kappa B deregulation in haematological malignancies and will highlight what is still unclear in this field, 20 years after the discovery of this transcription factor. (c) 2006 Elsevier Inc. All rights reserved.

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收藏

页码：1069 / 1080

页数：12

相关论文

共 92 条

[41] Expression of the Bcl-3 proto-oncogene suppresses p53 activation [J].

Kashatus, D ;

Cogswell, P ;

Baldwin, AS .

GENES & DEVELOPMENT, 2006, 20 (02) :225-235

[42] Mechanisms of bcr-Abl-mediated NF-κB/Re1 activation [J].

Kirchner, D ;

Duyster, J ;

Ottmann, O ;

Schmid, RM ;

Bergmann, L ;

Munzert, G .

EXPERIMENTAL HEMATOLOGY, 2003, 31 (06) :504-511

[43] Transcription factor NF-κB is constitutively activated in acute lymphoblastic leukemia cells [J].

Kordes, U ;

Krappmann, D ;

Heissmeyer, V ;

Ludwig, WD ;

Scheidereit, C .

LEUKEMIA, 2000, 14 (03) :399-402

[44] Molecular mechanisms of constitutive NF-κB/Rel activation in Hodgkin/Reed-Sternberg cells [J].

Krappmann, D ;

Emmerich, F ;

Kordes, U ;

Scharschmidt, E ;

Dörken, B ;

Scheidereit, C .

ONCOGENE, 1999, 18 (04) :943-953

[45] Exclusive ubiquitination and sumoylation on overlapping lysine residues mediate NF-κB activation by the human T-cell leukemia virus tax oncoprotein [J].

Lamsoul, I ;

Lodewick, J ;

Lebrun, S ;

Brasseur, R ;

Burny, A ;

Gaynor, RB ;

Bex, F .

MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (23) :10391-10406

[46] NF-κB regulation in the immune system [J].

Li, QT ;

Verma, IM .

NATURE REVIEWS IMMUNOLOGY, 2002, 2 (10) :725-734

[47]

LU D, 1991, ONCOGENE, V6, P1235

[48] Epstein-Barr virus latent infection membrane protein 1 TRAF-binding site induces NIK/IKKα-dependent noncanonical NF-κB activation [J].

Luftig, M ;

Yasui, T ;

Soni, V ;

Kang, MS ;

Jacobson, N ;

Cahir-McFarland, E ;

Seed, B ;

Kieff, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (01) :141-146

[49] Differential expression of NF-κB pathway genes among peripheral T-cell lymphomas [J].

Martínez-Delgado, B ;

Cuadros, M ;

Honrado, E ;

de la Parte, AR ;

Roncador, G ;

Alves, J ;

Castrillo, JM ;

Rivas, C ;

Benítez, J .

LEUKEMIA, 2005, 19 (12) :2254-2263

[50] Elevated NF-κB p50 complex formation and Bcl-3 expression in classical Hodgkin, anaplastic large-cell, and other peripheral T-cell lymphomas [J].

Mathas, S ;

Jöhrens, K ;

Joos, S ;

Lietz, A ;

Hummel, F ;

Janz, M ;

Jundt, F ;

Anagnostopoulos, I ;

Bommert, K ;

Lichter, P ;

Stein, H ;

Scheidereit, C ;

Dörken, B .

BLOOD, 2005, 106 (13) :4287-4293

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