Diastereoselective formation of indanes from arylboronate esters catalyzed by rhodium(I) in aqueous media

被引：46

作者：

Lautens, M ^{[1
]}

Mancuso, J ^{[1
]}

机构：

[1] Univ Toronto, Dept Chem, Davenport Chem Labs, Toronto, ON M5S 3H6, Canada

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 12期

关键词：

D O I：

10.1021/ol0260627

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHIC] Arylboronate esters bearing a pendant Michael-acceptor alkene can add to norbornene and cyclize to give indane systems in yields ranging from 62% to 95% with high diastereomeric excess (>20:1). The reaction is performed in an organic/aqueous emulsion and catalyzed using [Rh(COD)Cl](2) with t-Bu-amphos chloride, a sterically bulky, electron-rich, water-soluble phosphine ligand.

引用

页码：2105 / 2108

页数：4

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