N-Allyl-N-tert-butyldimethylsilylamine for chiral ligand-controlled asymmetric conjugate addition to tert-butyl alkenoates

被引：37

作者：

Doi, H ^{[1
]}

Sakai, T ^{[1
]}

Yamada, K ^{[1
]}

Tomioka, K ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 6068501, Japan

来源：

CHEMICAL COMMUNICATIONS | 2004年 / 16期

关键词：

D O I：

10.1039/b405347h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The chiral ligand controlled asymmetric conjugate addition reaction of lithium N-allyl-N-(tert-butyldimethylsilyl) amide to alkenoates proceeded smoothly to give, after protodesilylation, the corresponding 3-allylaminoalkanoates with high enantioselectivities in high yields. The allyl group on the nitrogen atom was easily removable to afford 3-aminoalkanoates.

引用

页码：1850 / 1851

页数：2

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