Combination of Orthogonal ABB and ABC Multicomponent Reactions toward Efficient Divergent Synthesis of Dendrimers with Structural Diversity

被引：48

作者：

Deng, Xin-Xing ^{[1
]}

Du, Fu-Sheng ^{[1
]}

Li, Zi-Chen ^{[1
]}

机构：

[1] Peking Univ, Beijing Natl Lab Mol Sci BNLMS, Key Lab Polymer Chem & Phys,Minist Educ, Dept Polymer Sci & Engn,Coll Chem & Mol Engn, Beijing 100871, Peoples R China

来源：

ACS MACRO LETTERS | 2014年 / 3卷 / 07期

基金：

中国国家自然科学基金;

关键词：

PASSERINI 3-COMPONENT REACTION; FACILE SYNTHESIS; CLICK CHEMISTRY; DENDRITIC MACROMOLECULES; RAPID SYNTHESIS; POLYMERS; SEQUENCE; MACROCYCLIZATIONS; DEGRADATION; STRATEGY;

D O I：

10.1021/mz500207z

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Synthesis of dendrimers has been directed toward process efficiency and structural diversity. We report a divergent approach to the preparation of dendrimers with both ABC and ABB branching structures from nonbranching monomers by combination of efficient orthogonal ABC Passerini multicomponent reaction (MCR) and ABB thiol-yne MCR. Two kinds of dendrimers were synthesized efficiently: (1) dendrimers with two generations in three steps and (2) dendrimers with two generations containing one kind of internal functional group and two kinds of surface functional groups in five steps. This new synthetic method offers an efficient access to dendrimers with structural diversity.

引用

页码：667 / 670

页数：4

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