Drosophila dosage compensation: a complex voyage to the X chromosome

被引：209

作者：

Gelbart, Marnie E. ^{[1
]}

Kuroda, Mitzi I. ^{[1
]}

机构：

[1] Brigham & Womens Hosp, Dept Med, Div Genet, Boston, MA 02115 USA

来源：

DEVELOPMENT | 2009年 / 136卷 / 09期

关键词：

CHROMATIN ENTRY SITE; MSL COMPLEX; LETHAL COMPLEX; HISTONE H4; ACETYL TRANSFERASE; TARGET GENES; FUNCTIONAL-INTEGRATION; ACETYLTRANSFERASE MOF; NUCLEAR COMPARTMENT; INACTIVATION CENTER;

D O I：

10.1242/dev.029645

中图分类号：

Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程];

摘要：

Dosage compensation is the crucial process that equalizes gene expression from the X chromosome between males (XY) and females (XX). In Drosophila, the male-specific lethal (MSL) ribonucleoprotein complex mediates dosage compensation by upregulating transcription from the single male X chromosome approximately twofold. A key challenge is to understand how the MSL complex distinguishes the X chromosome from autosomes. Recent studies suggest that this occurs through a multi-step targeting mechanism that involves DNA sequence elements and epigenetic marks associated with transcription. This review will discuss the relative contributions of sequence elements and transcriptional marks to the complete pattern of MSL complex binding.

引用

页码：1399 / 1410

页数：12

共 116 条

[1]

Chromodomains are protein-RNA interaction modules [J].

Akhtar, A ;

Zink, D ;

Becker, PB .

NATURE, 2000, 407 (6802) :405-409

[2]

Activation of transcription through histone H4 acetylation by MOF, an acetyltransferase essential for dosage compensation in Drosophila [J].

Akhtar, A ;

Becker, PB .

MOLECULAR CELL, 2000, 5 (02) :367-375

[3]

The histone H4 acetyltransferase MOF uses a C2HC zinc finger for substrate recognition [J].

Akhtar, A ;

Becker, PB .

EMBO REPORTS, 2001, 2 (02) :113-118

[4]

High-resolution ChIP-chip analysis reveals that the Drosophila MSL complex selectively identifies active genes on the male X chromosome [J].

Alekseyenko, AA ;

Larschan, E ;

Lai, WR ;

Park, PJ ;

Kuroda, MI .

GENES & DEVELOPMENT, 2006, 20 (07) :848-857

[5]

A sequence motif within chromatin entry sites directs MSL establishment on the Drosophila X chromosome [J].

Alekseyenko, Artyom A. ;

Peng, Shouyong ;

Larschan, Erica ;

Gorchakov, Andrey A. ;

Lee, Ok-Kyung ;

Kharchenko, Peter ;

McGrath, Sean D. ;

Wang, Charlotte I. ;

Mardis, Elaine R. ;

Park, Peter J. ;

Kuroda, Mitzi I. .

CELL, 2008, 134 (04) :599-609

[6]

Genes expressed in neurons of adult male Drosophila [J].

Amrein, H ;

Axel, R .

CELL, 1997, 88 (04) :459-469

[7]

[Anonymous], 2005, WORMBOOK, DOI DOI 10.1895/WORMBOOK.1.8.1

[8]

Positive Selection at the Binding Sites of the Male-Specific Lethal Complex Involved in Dosage Compensation in Drosophila [J].

Bachtrog, Doris .

GENETICS, 2008, 180 (02) :1123-1129

[9]

A dynamic view of sex chromosome evolution [J].

Bachtrog, Doris .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2006, 16 (06) :578-585

[10]

Transcription-coupled methylation of histone H3 at lysine 36 regulates dosage compensation by enhancing recruitment of the MSL complex in Drosophila melanogaster [J].

Bell, Oliver ;

Conrad, Thomas ;

Kind, Jop ;

Wirbelauer, Christiane ;

Akhtar, Asifa ;

Schuebeler, Dirk .

MOLECULAR AND CELLULAR BIOLOGY, 2008, 28 (10) :3401-3409

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