Identification and characterisation of an inhibitor of interleukin-8: A receptor based approach.

被引：16

作者：

Attwood, MR

Borkakoti, N

Bottomley, GA

Conway, EA

Cowan, I

Fallowfield, AG

Handa, BK

Jones, PS

Keech, E

Kirtland, SJ

Williams, G

Wilson, FX

机构：

[1] ROCHE PROD LTD,DEPT MED CHEM,WELWYN GARDEN CIT AL7 3AY,HERTS,ENGLAND

[2] ROCHE PROD LTD,DEPT PHYS METHODS,WELWYN GARDEN CIT AL7 3AY,HERTS,ENGLAND

[3] ROCHE PROD LTD,DEPT BIOL,WELWYN GARDEN CIT AL7 3AY,HERTS,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 15期

关键词：

D O I：

10.1016/0960-894X(96)00331-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Identification of the extracellular domains of the interleukin-8 (IL-8) receptor led to the synthesis of several peptide sequences. A peptide derived from a single subdomain was shown to inhibit IL-8 binding and to act as a functional antagonist. Ala-scan and truncation strategies identified key areas of this peptide for further work. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：1869 / 1874

页数：6

共 28 条

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