Identification and characterisation of an inhibitor of interleukin-8: A receptor based approach.

被引:16
作者
Attwood, MR
Borkakoti, N
Bottomley, GA
Conway, EA
Cowan, I
Fallowfield, AG
Handa, BK
Jones, PS
Keech, E
Kirtland, SJ
Williams, G
Wilson, FX
机构
[1] ROCHE PROD LTD,DEPT MED CHEM,WELWYN GARDEN CIT AL7 3AY,HERTS,ENGLAND
[2] ROCHE PROD LTD,DEPT PHYS METHODS,WELWYN GARDEN CIT AL7 3AY,HERTS,ENGLAND
[3] ROCHE PROD LTD,DEPT BIOL,WELWYN GARDEN CIT AL7 3AY,HERTS,ENGLAND
关键词
D O I
10.1016/0960-894X(96)00331-9
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Identification of the extracellular domains of the interleukin-8 (IL-8) receptor led to the synthesis of several peptide sequences. A peptide derived from a single subdomain was shown to inhibit IL-8 binding and to act as a functional antagonist. Ala-scan and truncation strategies identified key areas of this peptide for further work. Copyright (C) 1996 Elsevier Science Ltd
引用
收藏
页码:1869 / 1874
页数:6
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