Identification and characterisation of an inhibitor of interleukin-8: A receptor based approach.

被引：16

作者：

Attwood, MR

Borkakoti, N

Bottomley, GA

Conway, EA

Cowan, I

Fallowfield, AG

Handa, BK

Jones, PS

Keech, E

Kirtland, SJ

Williams, G

Wilson, FX

机构：

[1] ROCHE PROD LTD,DEPT MED CHEM,WELWYN GARDEN CIT AL7 3AY,HERTS,ENGLAND

[2] ROCHE PROD LTD,DEPT PHYS METHODS,WELWYN GARDEN CIT AL7 3AY,HERTS,ENGLAND

[3] ROCHE PROD LTD,DEPT BIOL,WELWYN GARDEN CIT AL7 3AY,HERTS,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 15期

关键词：

D O I：

10.1016/0960-894X(96)00331-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Identification of the extracellular domains of the interleukin-8 (IL-8) receptor led to the synthesis of several peptide sequences. A peptide derived from a single subdomain was shown to inhibit IL-8 binding and to act as a functional antagonist. Ala-scan and truncation strategies identified key areas of this peptide for further work. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：1869 / 1874

页数：6

共 28 条

[21] PROPERTIES OF THE NOVEL PROINFLAMMATORY SUPERGENE INTERCRINE CYTOKINE FAMILY
OPPENHEIM, JJ
ZACHARIAE, COC
MUKAIDA, N
MATSUSHIMA, K
[J]. ANNUAL REVIEW OF IMMUNOLOGY, 1991, 9 : 617 - 648
[22] SEQUENCE ALIGNMENT OF THE G-PROTEIN COUPLED RECEPTOR SUPERFAMILY
PROBST, WC
SNYDER, LA
SCHUSTER, DI
BROSIUS, J
SEALFON, SC
[J]. DNA AND CELL BIOLOGY, 1992, 11 (01) : 1 - 20
[23] NEUTROPHIL ACTIVATION BY MONOMERIC INTERLEUKIN-8
RAJARATHNAM, K
SYKES, BD
KAY, CM
DEWALD, B
GEISER, T
BAGGIOLINI, M
CLARKLEWIS, I
[J]. SCIENCE, 1994, 264 (5155) : 90 - 92
[24] PREVENTION OF LUNG REPERFUSION INJURY IN RABBITS BY A MONOCLONAL-ANTIBODY AGAINST INTERLEUKIN-8
SEKIDO, N
MUKAIDA, N
HARADA, A
NAKANISHI, I
WATANABE, Y
MATSUSHIMA, K
[J]. NATURE, 1993, 365 (6447) : 654 - 657
[25] A POTENT NONPEPTIDE ANTAGONIST OF THE SUBSTANCE-P (NK1) RECEPTOR
SNIDER, RM
CONSTANTINE, JW
LOWE, JA
LONGO, KP
LEBEL, WS
WOODY, HA
DROZDA, SE
DESAI, MC
VINICK, FJ
SPENCER, RW
HESS, HJ
[J]. SCIENCE, 1991, 251 (4992) : 435 - 437
[26] WESTLIN WF, 1991, FASEB J, V5, pA1624
[27] Mutagenesis studies of interleukin-8 - Identification of a second epitope involved in receptor binding
Williams, G
Borkakoti, N
Bottomley, GA
Cowan, I
Fallowfield, AG
Jones, PS
Kirtland, SJ
Price, GJ
Price, L
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (16) : 9579 - 9586
[28] WILLIAMS GVM, UNPUB

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