A bacterial sulfonolipid triggers multicellular development in the closest living relatives of animals

被引:163
作者
Alegado, Rosanna A. [1 ]
Brown, Laura W. [2 ]
Cao, Shugeng [2 ]
Dermenjian, Renee K. [2 ]
Zuzow, Richard [3 ]
Fairclough, Stephen R. [1 ]
Clardy, Jon [2 ]
King, Nicole [1 ]
机构
[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA
[2] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA
[3] Stanford Univ, Dept Biochem, Sch Med, Stanford, CA 94305 USA
来源
ELIFE | 2012年 / 1卷
基金
美国国家卫生研究院;
关键词
COMPLETE GENOME SEQUENCE; FACTOR RECEPTOR ANTAGONISTS; SP-NOV; GEN; NOV; MARINE BACTERIUM; FAMILY FLAVOBACTERIACEAE; SPHINGOLIPID METABOLISM; ALKALIPHILIC BACTERIUM; SIGNAL-TRANSDUCTION; MEMBRANE-VESICLES;
D O I
10.7554/eLife.00013
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Bacterially-produced small molecules exert profound influences on animal health, morphogenesis, and evolution through poorly understood mechanisms. In one of the closest living relatives of animals, the choanoflagellate Salpingoeca rosetta, we find that rosette colony development is induced by the prey bacterium Algoriphagus machipongonensis and its close relatives in the Bacteroidetes phylum. Here we show that a rosette inducing factor (RIF-1) produced by A. machipongonensis belongs to the small class of sulfonolipids, obscure relatives of the better known sphingolipids that play important roles in signal transmission in plants, animals, and fungi. RIF-1 has extraordinary potency (femtomolar, or 10(-15) M) and S. rosetta can respond to it over a broad dynamic range-nine orders of magnitude. This study provides a prototypical example of bacterial sulfonolipids triggering eukaryotic morphogenesis and suggests molecular mechanisms through which bacteria may have contributed to the evolution of animals.
引用
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页数:16
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