Nitroxide-labeled guanine as an ESR spin probe for structural study of DNA

被引：31

作者：

Okamoto, A

Inasaki, T

Saito, I ^{[1
]}

机构：

[1] Kyoto Univ, Fac Engn, Dept Synthet Chem & Biol Chem, Kyoto 6158510, Japan

[2] Japan Sci & Technol Corp, SORST, Kyoto 6158510, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 13期

关键词：

G-rich DNA; nitroxide spin label; quadruplex; artificial nucleoside;

D O I：

10.1016/j.bmcl.2004.04.076

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A guanine derivative with a covalently linked nitroxide spin label has been devised. The spin label was incorporated into oligodeoxynucleotides by post-synthetic modification. The local environment of a variety of G-rich DNA is detectable by ESR using this spin probe. (C) 2004 Elsevier Ltd. All rights reserved.

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页码：3415 / 3418

页数：4

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