Aging and Cancer: Converging Routes to Disease Prevention

被引：10

作者：

Chobotova, Katya ^{[1
]}

机构：

[1] Univ Oxford Wolfson Coll, Oxford OX2 6UD, England

来源：

INTEGRATIVE CANCER THERAPIES | 2009年 / 8卷 / 02期

关键词：

aging; cancer; oxidative stress; psychological stress; antioxidants; caloric restriction; physical activity; integrative; AGE-RELATED DISEASES; CALORIC RESTRICTION; TAI-CHI; PHYSICAL-ACTIVITY; OXIDATIVE STRESS; TELOMERE LENGTH; CARDIOVASCULAR-DISEASE; CELLULAR SENESCENCE; MAMMALIAN TARGET; TUMOR-SUPPRESSOR;

D O I：

10.1177/1534735409335505

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

An integrative approach to the combined challenges of aging, cancer and stress is a necessary part of a global vision of wellness. Recent research into the mechanisms of aging, cancer and stress has established the biological links between these processes. Understanding these links is an important stepping-stone for developing approaches and therapies that ensure wellness throughout all stages of aging. This paper will consider the most recent developments in research into the molecular mechanisms common to aging and cancer and will discuss the effectiveness of natural approaches for preventing disease. Metabolic regulators as well as nutrient and energy sensors are involved in the processes of aging and cancer, and these are open to external manipulation and control. It is now becoming possible to demonstrate how nutrition, physical activity and stress control can lead to disease-free aging.

引用

页码：115 / 122

页数：8

共 89 条

[61] Oxidative damage in telomeric DNA disrupts recognition by TRF1 and TRF2 [J].