Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36

被引：186

作者：

Means, Terry K. ^{[1
,2
,3
,6
]}

Mylonakis, Eleftherios ^{[4
]}

Tampakakis, Emmanouil ^{[4
]}

Colvin, Richard A. ^{[1
,2
,3
]}

Seung, Edward ^{[1
,2
,3
]}

Puckett, Lindsay ^{[1
,2
,3
]}

Tai, Melissa F. ^{[1
,2
,3
]}

Stewart, Cameron R. ^{[5
]}

Pukkila-Worley, Read ^{[4
]}

Hickman, Suzanne E. ^{[1
,2
,3
]}

Moore, Kathryn J. ^{[5
]}

Calderwood, Stephen B. ^{[4
]}

Hacohen, Nir ^{[1
,2
,3
,6
]}

Luster, Andrew D. ^{[1
,2
,3
]}

El Khoury, Joseph ^{[1
,2
,3
,4
]}

机构：

[1] Massachusetts Gen Hosp, Ctr Immunol & Inflammatory Dis, Charlestown, MA 02129 USA

[2] Massachusetts Gen Hosp, Div Rheumatol Allergy & Immunol, Charlestown, MA 02129 USA

[3] Harvard Univ, Sch Med, Charlestown, MA 02129 USA

[4] Massachusetts Gen Hosp, Div Infect Dis, Boston, MA 02114 USA

[5] Massachusetts Gen Hosp, Lipid Metab Unit, Boston, MA 02114 USA

[6] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2009年 / 206卷 / 03期

基金：

美国国家卫生研究院;

关键词：

CRYPTOCOCCUS-NEOFORMANS INFECTION; LOW-DENSITY LIPOPROTEINS; TOLL-LIKE RECEPTOR-2; CAENORHABDITIS-ELEGANS; CANDIDA-ALBICANS; HOST-DEFENSE; IN-VIVO; DENDRITIC CELLS; BETA-GLUCANS; INFLAMMATORY RESPONSES;

D O I：

10.1084/jem.20082109

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Receptors involved in innate immunity to fungal pathogens have not been fully elucidated. We show that the Caenorhabditis elegans receptors CED-1 and C03F11.3, and their mammalian orthologues, the scavenger receptors SCARF1 and CD36, mediate host defense against two prototypic fungal pathogens, Cryptococcus neoformans and Candida albicans. CED-1 and C03F11.1 mediated antimicrobial peptide production and were necessary for nematode survival after C. neoformans infection. SCARF1 and CD36 mediated cytokine production and were required for macrophage binding to C. neoformans, and control of the infection in mice. Binding of these pathogens to SCARF1 and CD36 was beta-glucan dependent. Thus, CED-1/SCARF1 and C03F11.3/CD36 are beta-glucan binding receptors and define an evolutionarily conserved pathway for the innate sensing of fungal pathogens.

引用

页码：637 / 653

页数：17

共 60 条

[41] Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cells [J].

Re, F ;

Strominger, JL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (40) :37692-37699

[42]

Rice PJ, 2002, J LEUKOCYTE BIOL, V72, P140

[43] Changing epidemiology of systemic fungal infections [J].

Richardson, M. ;

Lass-Floerl, C. .

CLINICAL MICROBIOLOGY AND INFECTION, 2008, 14 :5-24

[44] Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans [J].

Saijo, Shinobu ;

Fujikado, Noriyuki ;

Furuta, Takahisa ;

Chung, Soo-hyun ;

Kotaki, Hayato ;

Seki, Keisuke ;

Sudo, Katsuko ;

Akira, Shizuo ;

Adachi, Yoshiyuki ;

Ohno, Naohito ;

Kinjo, Takeshi ;

Nakamura, Kiwamu ;

Kawakami, Kazuyoshi ;

Iwakura, Yoichiro .

NATURE IMMUNOLOGY, 2007, 8 (01) :39-46

[45] Role of extracellular phospholipases and mononuclear phagocytes in dissemination of cryptococcosis in a murine model [J].

Santangelo, R ;

Zoellner, H ;

Sorrell, T ;

Wilson, C ;

Donald, C ;

Djordjevic, J ;

Shounan, Y ;

Wright, L .

INFECTION AND IMMUNITY, 2004, 72 (04) :2229-2239

[46] Response to Staphylococcus aureus requires CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain [J].

Stuart, LM ;

Deng, JS ;

Silver, JM ;

Takahashi, K ;

Tseng, AA ;

Hennessy, EJ ;

Ezekowitz, RAB ;

Moore, KJ .

JOURNAL OF CELL BIOLOGY, 2005, 170 (03) :477-485

[47] A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection [J].

Suzuki, H ;

Kurihara, Y ;

Takeya, M ;

Kamada, N ;

Kataoka, M ;

Jishage, K ;

Ueda, O ;

Sakaguchi, H ;

Higashi, T ;

Suzuki, T ;

Takashima, Y ;

Kawabe, Y ;

Cynshi, O ;

Wada, Y ;

Honda, M ;

Kurihara, H ;

Aburatani, H ;

Doi, T ;

Matsumoto, A ;

Azuma, S ;

Noda, T ;

Toyoda, Y ;

Itakura, H ;

Yazaki, Y ;

Horiuchi, S ;

Takahashi, K ;

Kruijt, JK ;

vanBerkel, TJC ;

Steinbrecher, UP ;

Ishibashi, S ;

Maeda, N ;

Gordon, S ;

Kodama, T .

NATURE, 1997, 386 (6622) :292-296

[48] Scavenger receptor expressed by endothelial cells I (SREC-I) mediates the uptake of acetylated low density lipoproteins by macrophages stimulated with lipopolysaccharide [J].

Tamura, Y ;

Osuga, J ;

Adachi, H ;

Tozawa, R ;

Takanezawa, Y ;

Ohashi, K ;

Yahagi, N ;

Sekiya, M ;

Okazaki, H ;

Tomita, S ;

Iizuka, Y ;

Koizumi, H ;

Inaba, T ;

Yagyu, H ;

Kamada, N ;

Suzuki, H ;

Shimano, H ;

Kadowaki, T ;

Tsujimoto, M ;

Arai, H ;

Yamada, N ;

Ishibashi, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (30) :30938-30944

[49] Dectin-1 is required for β-glucan recognition and control of fungal infection [J].

Taylor, Philip R. ;

Tsoni, S. Vicky ;

Willment, Janet A. ;

Dennehy, Kevin M. ;

Rosas, Marcela ;

Findon, Helen ;

Haynes, Ken ;

Steele, Chad ;

Botto, Marina ;

Gordon, Siamon ;

Brown, Gordon D. .

NATURE IMMUNOLOGY, 2007, 8 (01) :31-38

[50] Protection from lethal gram-positive infection by macrophage scavenger receptor-dependent phagocytosis [J].

Thomas, CA ;

Li, YM ;

Kodama, T ;

Suzuki, H ;

Silverstein, SC ;

El Khoury, J .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 191 (01) :147-155

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