Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36

被引：186

作者：

Means, Terry K. ^{[1
,2
,3
,6
]}

Mylonakis, Eleftherios ^{[4
]}

Tampakakis, Emmanouil ^{[4
]}

Colvin, Richard A. ^{[1
,2
,3
]}

Seung, Edward ^{[1
,2
,3
]}

Puckett, Lindsay ^{[1
,2
,3
]}

Tai, Melissa F. ^{[1
,2
,3
]}

Stewart, Cameron R. ^{[5
]}

Pukkila-Worley, Read ^{[4
]}

Hickman, Suzanne E. ^{[1
,2
,3
]}

Moore, Kathryn J. ^{[5
]}

Calderwood, Stephen B. ^{[4
]}

Hacohen, Nir ^{[1
,2
,3
,6
]}

Luster, Andrew D. ^{[1
,2
,3
]}

El Khoury, Joseph ^{[1
,2
,3
,4
]}

机构：

[1] Massachusetts Gen Hosp, Ctr Immunol & Inflammatory Dis, Charlestown, MA 02129 USA

[2] Massachusetts Gen Hosp, Div Rheumatol Allergy & Immunol, Charlestown, MA 02129 USA

[3] Harvard Univ, Sch Med, Charlestown, MA 02129 USA

[4] Massachusetts Gen Hosp, Div Infect Dis, Boston, MA 02114 USA

[5] Massachusetts Gen Hosp, Lipid Metab Unit, Boston, MA 02114 USA

[6] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2009年 / 206卷 / 03期

基金：

美国国家卫生研究院;

关键词：

CRYPTOCOCCUS-NEOFORMANS INFECTION; LOW-DENSITY LIPOPROTEINS; TOLL-LIKE RECEPTOR-2; CAENORHABDITIS-ELEGANS; CANDIDA-ALBICANS; HOST-DEFENSE; IN-VIVO; DENDRITIC CELLS; BETA-GLUCANS; INFLAMMATORY RESPONSES;

D O I：

10.1084/jem.20082109

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Receptors involved in innate immunity to fungal pathogens have not been fully elucidated. We show that the Caenorhabditis elegans receptors CED-1 and C03F11.3, and their mammalian orthologues, the scavenger receptors SCARF1 and CD36, mediate host defense against two prototypic fungal pathogens, Cryptococcus neoformans and Candida albicans. CED-1 and C03F11.1 mediated antimicrobial peptide production and were necessary for nematode survival after C. neoformans infection. SCARF1 and CD36 mediated cytokine production and were required for macrophage binding to C. neoformans, and control of the infection in mice. Binding of these pathogens to SCARF1 and CD36 was beta-glucan dependent. Thus, CED-1/SCARF1 and C03F11.3/CD36 are beta-glucan binding receptors and define an evolutionarily conserved pathway for the innate sensing of fungal pathogens.

引用

页码：637 / 653

页数：17

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