Tailoring Functional Interlayers in Organic Field-Effect Transistor Biosensors

被引:73
作者
Magliulo, Maria [1 ]
Manoli, Kyriaki [1 ]
Macchia, Eleonora [1 ,2 ]
Palazzo, Gerardo [1 ]
Torsi, Luisa [1 ]
机构
[1] Univ Bari Aldo Moro, I-470125 Bari, Italy
[2] Univ Bari A Moro, Dipartimento Interateneo Fis M Merlin, I-470125 Bari, Italy
关键词
THIN-FILM TRANSISTORS; SELF-ASSEMBLED MONOLAYERS; ELECTROCHEMICAL TRANSISTORS; DNA; ELECTRONICS; INTERFACE; PERFORMANCE; DIELECTRICS; PENTACENE; INTEGRATION;
D O I
10.1002/adma.201403477
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
This review aims to provide an update on the development involving dielectric/ organic semiconductor (OSC) interfaces for the realization of biofunctional organic field-effect transistors (OFETs). Specific focus is given on biointerfaces and recent technological approaches where biological materials serve as interlayers in back-gated OFETs for biosensing applications. Initially, to better understand the effects produced by the presence of biomolecules deposited at the dielectric/OSC interfacial region, the tuning of the dielectric surface properties by means of self-assembled monolayers is discussed. Afterward, emphasis is given to the modification of solid-state dielectric surfaces, in particular inorganic dielectrics, with biological molecules such as peptides and proteins. Special attention is paid on how the presence of an interlayer of biomolecules and bioreceptors underneath the OSC impacts on the charge transport and sensing performance of the device. Moreover, naturally occurring materials, such as carbohydrates and DNA, used directly as bulk gating materials in OFETs are reviewed. The role of metal contact/OSC interface in the overall performance of OFET-based sensors is also discussed.
引用
收藏
页码:7528 / 7551
页数:24
相关论文
共 98 条
[1]  
Alberts B., 2008, Molecular Biology of the Cell, V5th
[2]   Volatile general anesthetic sensing with organic field-effect transistors integrating phospholipid membranes [J].
Angione, Maria Daniela ;
Magliulo, Maria ;
Cotrone, Serafina ;
Mallardi, Antonia ;
Altamura, Davide ;
Giannini, Cinzia ;
Cioffi, Nicola ;
Sabbatini, Luigia ;
Gobeljic, Danka ;
Scamarcio, Gaetano ;
Palazzo, Gerardo ;
Torsi, Luisa .
BIOSENSORS & BIOELECTRONICS, 2013, 40 (01) :303-307
[3]   Interfacial electronic effects in functional biolayers integrated into organic field-effect transistors [J].
Angione, Maria Daniela ;
Cotrone, Serafina ;
Magliulo, Maria ;
Mallardi, Antonia ;
Altamura, Davide ;
Giannini, Cinzia ;
Cioffi, Nicola ;
Sabbatini, Luigia ;
Fratini, Emiliano ;
Baglioni, Piero ;
Scamarcio, Gaetano ;
Palazzo, Gerardo ;
Torsi, Luisa .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (17) :6429-6434
[4]   Field-effect detection of chemical species with hybrid organic/inorganic transistors [J].
Bartic, C ;
Campitelli, A ;
Borghs, S .
APPLIED PHYSICS LETTERS, 2003, 82 (03) :475-477
[5]   The role of charge and spin migration in DNA radiation damage [J].
Becker, David ;
Adhikary, Amitava ;
Sevilla, Michael D. .
CHARGE MIGRATION IN DNA: PERSPECTIVES FROM PHYSICS, CHEMISTRY, AND BIOLOGY, 2007, :139-175
[6]   Operational Stability of Organic Field-Effect Transistors [J].
Bobbert, Peter A. ;
Sharma, Abhinav ;
Mathijssen, Simon G. J. ;
Kemerink, Martijn ;
de Leeuw, Dago M. .
ADVANCED MATERIALS, 2012, 24 (09) :1146-1158
[7]   Integration of silk protein in organic and light-emitting transistors [J].
Capelli, R. ;
Amsden, J. J. ;
Generali, G. ;
Toffanin, S. ;
Benfenati, V. ;
Muccini, M. ;
Kaplan, D. L. ;
Omenetto, F. G. ;
Zamboni, R. .
ORGANIC ELECTRONICS, 2011, 12 (07) :1146-1151
[8]   Chicken Albumen Dielectrics in Organic Field-Effect Transistors [J].
Chang, Jer-Wei ;
Wang, Cheng-Guang ;
Huang, Chong-Yu ;
Tsai, Tzung-Da ;
Guo, Tzung-Fang ;
Wen, Ten-Chin .
ADVANCED MATERIALS, 2011, 23 (35) :4077-+
[9]   Absence of dc-conductivity in λ-DNA [J].
de Pablo, PJ ;
Moreno-Herrero, F ;
Colchero, J ;
Gomez-Herrero, J ;
Herrero, P ;
Baró, AM ;
Ordejón, P ;
Soler, JM ;
Artacho, E .
PHYSICAL REVIEW LETTERS, 2000, 85 (23) :4992-4995
[10]   Charge sensing by organic charge-modulated field effect transistors: application to the detection of bio-related effects [J].
Demelas, Monia ;
Lai, Stefano ;
Spanu, Andrea ;
Martinoia, Sergio ;
Cosseddu, Piero ;
Barbaro, Massimo ;
Bonfiglio, Annalisa .
JOURNAL OF MATERIALS CHEMISTRY B, 2013, 1 (31) :3811-3819