Caveolae and caveolins in the cardiovascular system

被引：257

作者：

Gratton, JP

Bernatchez, P

Sessa, WC

机构：

[1] Yale Univ, Sch Med, Boyer Ctr Mol Med, Dept Pharmacol, New Haven, CT 06536 USA

[2] Inst Rech Clin Montreal, Lab Endothelial Cell Biol, Montreal, PQ H2W 1R7, Canada

[3] Yale Univ, Sch Med, Boyer Ctr Mol Med, Program Vasc Cell Signaling & Therapeut, New Haven, CT 06536 USA

来源：

CIRCULATION RESEARCH | 2004年 / 94卷 / 11期

关键词：

caveolae; caveolins; signaling; phenotypes; nitric oxide;

D O I：

10.1161/01.RES.0000129178.56294.17

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Caveolae and the caveolae coat proteins, caveolins, are putatively implicated in many cellular processes, including transcytosis of macromolecules, cholesterol transport, and signal transduction. Recent insights into the physiological and pathophysiological roles of these organelles and the caveolins from genetically modified mice suggest that they may be profoundly important for postnatal cardiovascular function, including endothelial barrier function, regulation of nitric oxide synthesis, cholesterol metabolism, and cardiac function.

引用

页码：1408 / 1417

页数：10

共 123 条

[21] Feng YY, 1999, INVEST OPHTH VIS SCI, V40, P157
[22] Feron O, 2001, CIRCULATION, V103, P113
[23] Modulation of the endothelial nitric-oxide synthase caveolin interaction in cardiac myocytes - Implications for the autonomic regulation of heart rate
Feron, O
Dessy, C
Opel, DJ
Arstall, MA
Kelly, RA
Michel, T
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (46) : 30249 - 30254
[24] Endothelial nitric oxide synthase targeting to caveolae - Specific interactions with caveolin isoforms in cardiac myocytes and endothelial cells
Feron, O
Belhassen, L
Kobzik, L
Smith, TW
Kelly, RA
Michel, T
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (37) : 22810 - 22814
[25] Cellular cholesterol efflux
Fielding, CJ
Fielding, PE
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2001, 1533 (03): : 175 - 189
[26] Unbiased quantitative proteomics of lipid rafts reveals high specificity for signaling factors
Foster, LJ
de Hoog, CL
Mann, M
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (10) : 5813 - 5818
[27] Genetic ablation of caveolin-1 confers protection against atherosclerosis
Frank, PG
Lee, H
Park, DS
Tandon, NN
Scherer, PE
Lisanti, MP
[J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2004, 24 (01) : 98 - 105
[28] Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability
Fukumura, D
Gohongi, T
Kadambi, A
Izumi, Y
Ang, J
Yun, CO
Buerk, DG
Huang, PL
Jain, RK
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (05) : 2604 - 2609
[29] Fulton D, 2001, J PHARMACOL EXP THER, V299, P818
[30] Cholesterol depletion of caveolae causes hyperactivation of extracellular signal-related kinase (ERK)
Furuchi, T
Anderson, RGW
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (33) : 21099 - 21104

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