Caveolae and caveolins in the cardiovascular system

被引：257

作者：

Gratton, JP

Bernatchez, P

Sessa, WC

机构：

[1] Yale Univ, Sch Med, Boyer Ctr Mol Med, Dept Pharmacol, New Haven, CT 06536 USA

[2] Inst Rech Clin Montreal, Lab Endothelial Cell Biol, Montreal, PQ H2W 1R7, Canada

[3] Yale Univ, Sch Med, Boyer Ctr Mol Med, Program Vasc Cell Signaling & Therapeut, New Haven, CT 06536 USA

来源：

CIRCULATION RESEARCH | 2004年 / 94卷 / 11期

关键词：

caveolae; caveolins; signaling; phenotypes; nitric oxide;

D O I：

10.1161/01.RES.0000129178.56294.17

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Caveolae and the caveolae coat proteins, caveolins, are putatively implicated in many cellular processes, including transcytosis of macromolecules, cholesterol transport, and signal transduction. Recent insights into the physiological and pathophysiological roles of these organelles and the caveolins from genetically modified mice suggest that they may be profoundly important for postnatal cardiovascular function, including endothelial barrier function, regulation of nitric oxide synthesis, cholesterol metabolism, and cardiac function.

引用

收藏

页码：1408 / 1417

页数：10

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