Trinucleotide repeats and other microsatellites in yeasts

被引:29
作者
Richard, GF
Hennequin, C
Thierry, A
Dujon, B
机构
[1] Univ Paris 06, URA 1300 CNRS, UFR 927, Inst Pasteur,Unite Genet Mol Levures, F-75724 Paris 15, France
[2] CHU Amiens, Serv Parasitol Mycol & Med Voyages, F-80054 Amiens, France
关键词
trinucleotide repeats; microsatellites; mycology; replication slippage; recombination;
D O I
10.1016/S0923-2508(99)00131-X
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Microsatellites are direct tandem DNA repeats found in all genomes. A particular class of microsatellites, called trinucleotide repeats, is responsible for a number of neurological disorders in humans. We review here our current state of knowledge on trinucleotide repeat instability, and discuss the molecular mechanisms that may be involved in trinucleotide repeat expansions leading to fatal diseases in humans. We also present original data on microsatellite distribution in several microbial genomes, and on the use of microsatellites as physical markers to accurately and easily genotype yeast strains. (C) 1999 Editions scientifiques et medicales Elsevier SAS.
引用
收藏
页码:589 / 602
页数:14
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