Pharmaceutical Cocrystals and Their Physicochemical Properties

被引：1262

作者：

Schultheiss, Nate ^{[1
]}

Newman, Ann ^{[2
]}

机构：

[1] SSCI Inc, Div Aptuit, W Lafayette, IN USA

[2] Seventh St Dev Grp, Lafayette, IN USA

来源：

CRYSTAL GROWTH & DESIGN | 2009年 / 9卷 / 06期

关键词：

CAMBRIDGE STRUCTURAL DATABASE; CO-CRYSTAL; MELTING-POINTS; VERSATILE TOOLS; X-RAY; SOLUBILITY; ACID; SACCHARIN; CARBAMAZEPINE; POLYMORPHISM;

D O I：

10.1021/cg900129f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Over the last 20 years, the number of publications outlining the advances in design strategies, growing techniques, and characterization of cocrystals has continued to increase significantly within the crystal engineering field. However, only within the last decade have cocrystals found their place in pharmaceuticals, primarily due to their ability to alter physicochemical properties without compromising the structural integrity of the active pharmaceutical ingredient (API) and thus, possibly, the bioactivity. This review article will highlight and discuss the advances made over the last 10 years pertaining to physical and chemical property improvements through pharmaceutical cocrystalline materials and, hopefully, draw closer the fields of crystal engineering and pharmaceutical sciences.

引用

页码：2950 / 2967

页数：18

共 96 条

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