Mouse thyroglobulin: Conservation of sequence homology in C-terminal immunogenic regions of thyroglobulin

被引：10

作者：

Kuppers, RC ^{[1
]}

Hu, Q ^{[1
]}

Rose, NR ^{[1
]}

机构：

[1] JOHNS HOPKINS MED INST,DEPT PATHOL,BALTIMORE,MD 21205

来源：

AUTOIMMUNITY | 1996年 / 23卷 / 03期

关键词：

mouse thyroglobulin; cDNA sequence; autoimmune thyroiditis; T cell epitopes;

D O I：

10.3109/08916939608995341

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

cDNA encoding 287 amino acids of the C-terminus of mouse thyroglobulin was cloned and sequenced. The amino acid homology between mouse and rat thyroglobulin was 96%, and was 78% between mouse and human. It was found that mouse thyroglobulin completely shared homology with two thyroiditogenic peptides described by other investigators. These findings are consistent with our hypothesis that in murine experimental thyroiditis, the primary thyroiditogenic epitopes are encoded by mouse-specific regions of thyroglobulin.

引用

页码：175 / 180

页数：6

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