Apolipoprotein E gene polymorphism and polycystic ovary syndrome patients in Western Anatolia, Turkey

被引：20

作者：

Cetinkalp, Sevki ^{[1
]}

Karadeniz, Muammer ^{[1
]}

Erdogan, Mehmet ^{[1
]}

Zengi, Ayhan ^{[1
]}

Cetintas, Vildan ^{[2
]}

Tetik, Asli ^{[2
]}

Eroglu, Zuhal ^{[2
]}

Kosova, Buket ^{[2
]}

Ozgen, A. Gokhan ^{[1
]}

Saygili, Fusun ^{[1
]}

Yilmaz, Candeger ^{[1
]}

机构：

[1] Ege Univ Hosp, Div Internal Med, Dept Endocrinol & Metab Dis, TR-35100 Izmir, Turkey

[2] Ege Univ Hosp, Dept Med Biol, Izmir, Turkey

来源：

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS | 2009年 / 26卷 / 01期

关键词：

Apolipoprotein E gene; Cardiovascular risk factors; Hyperlipidemia; Polycystic ovary syndrome; C-REACTIVE PROTEIN; CARDIOVASCULAR RISK; INSULIN-RESISTANCE; PLASMA-LIPIDS; YOUNG-WOMEN; E ALLELES; POPULATION; DISEASE; PREVALENCE; ENDOCRINE;

D O I：

10.1007/s10815-008-9280-8

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学];

摘要：

Dyslipidemia, cardiovascular disease and hypertension are more frequently seen in patients with PCOS than in normal patients. We aimed at evaluating the distribution of Apo E alleles that can influence cardiovascular risk of the PCOS patients and control subjects. In this study, 129 young women with PCOS and 91 healthy women were included. In all subjects we performed hormonal, biochemical and Apo E genetic analysis. The Apo E3 allele was found at a significantly higher frequency in the PCOS patient group compared with the control group. The Apo E2 allele was found at a significantly higher frequency in the control group compared with the patient group with PCOS. Although there were genotype and allele differences between control and patient groups in this study, no statistically significant change was determined in lipid and other cardiovascular risk factors in connection with allele and genotype.

引用

页码：1 / 6

页数：6

共 35 条

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