Apolipoprotein E structure: insights into function

被引：450

作者：

Hatters, Danny M.

Peters-Libeu, Clare A.

Weisgraber, Karl H. ^{[1
]}

机构：

[1] Gladstone Inst Neurol Dis, San Francisco, CA 94158 USA

[2] Gladstone Inst Cardiovasc Dis, San Francisco, CA 94158 USA

[3] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94143 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2006年 / 31卷 / 08期

关键词：

D O I：

10.1016/j.tibs.2006.06.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human apolipoprotein E (apoE) is a member of the family of soluble apolipoproteins. Through its interaction with members of the low-density lipoprotein receptor family, apoE has a key role in lipid transport both in the plasma and in the central nervous system. Its three common structural isoforms differentially affect the risk of developing atherosclerosis and neuro-degenerative disorders, including Alzheimer's disease. Because the function of apoE is dictated by its structure, understanding the structural properties of apoE and its isoforms is required both to determine its role in disease and for the development of therapeutic strategies.

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页码：445 / 454

页数：10

相关论文

共 85 条

[1] Comparison of the stabilities and unfolding pathways of human apolipoprotein E isoforms by differential scanning calorimetry and circular dichroism [J].

Acharya, P ;

Segall, ML ;

Zaiou, M ;

Morrow, J ;

Weisgraber, KH ;

Phillips, MC ;

Lund-Katz, S ;

Snow, J .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2002, 1584 (01) :9-19

[2] RETRACTED: Crystal structure of human apolipoprotein A-I: Insights into its protective effect against cardiovascular diseases (Retracted article. See vol. 115, pg. E6966, 2018) [J].

Ajees, AA ;

Anantharamaiah, GM ;

Mishra, VK ;

Hussain, MM ;

Murthy, HMK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (07) :2126-2131

[3] Crystal structure of truncated human apolipoprotein A-I suggests a lipid-bound conformation [J].

Borhani, DW ;

Rogers, DP ;

Engler, JA ;

Brouillette, CG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (23) :12291-12296

[4] Neuron-specific apolipoprotein E4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice [J].

Brecht, WJ ;

Harris, FM ;

Chang, SJ ;

Tesseur, I ;

Yu, GQ ;

Xu, Q ;

Fish, JD ;

Wyss-Coray, T ;

Buttini, M ;

Mucke, L ;

Mahley, RW ;

Huang, YD .

JOURNAL OF NEUROSCIENCE, 2004, 24 (10) :2527-2534

[5] MOLECULAR-STRUCTURE OF AN APOLIPOPROTEIN DETERMINED AT 2.5-A RESOLUTION [J].

BREITER, DR ;

KANOST, MR ;

BENNING, MM ;

WESENBERG, G ;

LAW, JH ;

WELLS, MA ;

RAYMENT, I ;

HOLDEN, HM .

BIOCHEMISTRY, 1991, 30 (03) :603-608

[6]

Buttini M, 1999, J NEUROSCI, V19, P4867

[7] GENE DOSE OF APOLIPOPROTEIN-E TYPE-4 ALLELE AND THE RISK OF ALZHEIMERS-DISEASE IN LATE-ONSET FAMILIES [J].

CORDER, EH ;

SAUNDERS, AM ;

STRITTMATTER, WJ ;

SCHMECHEL, DE ;

GASKELL, PC ;

SMALL, GW ;

ROSES, AD ;

HAINES, JL ;

PERICAKVANCE, MA .

SCIENCE, 1993, 261 (5123) :921-923

[8] Apoliprotein structural organisation in high density lipoproteins: belts, bundles, hinges and hairpins [J].

Davidson, WS ;

Silva, RAGD .

CURRENT OPINION IN LIPIDOLOGY, 2005, 16 (03) :295-300

[9] The structural basis of protein folding and its links with human disease [J].

Dobson, CM .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2001, 356 (1406) :133-145

[10] A nontransgenic mouse model shows inducible amyloid-β (Aβ) peptide deposition and elucidates the role of apolipoprotein E in the amyloid cascade [J].

Dolev, I ;

Michaelson, DM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (38) :13909-13914

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