A Modular Approach to Functionalized and Expanded Crown Ether Based Macrocycles Using Click Chemistry

被引：92

作者：

Binauld, Sandra ^{[1
]}

Hawker, Craig J. ^{[2
]}

Fleury, Etienne ^{[1
]}

Drockenmuller, Eric ^{[1
]}

机构：

[1] Univ Lyon 1, INSA Lyon Ingn Mat Polymeres, CNRS, UMR 5223, F-69622 Villeurbanne, France

[2] Univ Calif Santa Barbara, Dept Mat, Santa Barbara, CA 93106 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 36期

关键词：

click chemistry; copper; cyclization; iterative strategies; macrocycles; AZIDE-ALKYNE CYCLOADDITION; STEP-GROWTH POLYMERIZATION; PEPTIDE-BASED POLYMERS; SOLID-PHASE; 1,3-DIPOLAR CYCLOADDITIONS; RAFT POLYMERIZATION; MATERIALS SCIENCE; BLOCK-COPOLYMERS; TERMINAL ALKYNES; CYCLIC-PEPTIDES;

D O I：

10.1002/anie.200903156

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Tailored handcuffs: α-Azide-ω-alkyne oligomers are obtained in high yields from copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC), iterative chain growth, and protection-deprotection strategies. Intramolecular CuAAC under pseudo-high-dilution conditions then yields macrocycles with n=1-8 triazole units in the cyclic backbone (picture shows n=2; C gray, O red, N blue, H white). © 2009 Wiley-VCH Verlag GmbH & Co. KCaA.

引用

页码：6654 / 6658

页数：5

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