Tocopherols enhance neurogenesis in dentate gyrus of adult rats

被引：19

作者：

Cuppini, R ^{[1
]}

Ciaroni, S

Cecchini, T

Ambrogini, P

Ferri, P

Cuppini, C

Ninfali, P

Del Grande, P

机构：

[1] Univ Studi Urbino, Inst Sci Fisiol, I-61029 Urbino, Italy

[2] Univ Urbino, Ins Morphol Sci, I-61029 Urbino, Italy

[3] Univ Urbino, Inst Biol Chem Giorgio Fornaini, I-61029 Urbino, Italy

来源：

INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH | 2002年 / 72卷 / 03期

关键词：

hippocampus; granule cells; vitamin E; neurogenesis; cell death;

D O I：

10.1024/0300-9831.72.3.170

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

In the dentate gyrus of the mammalian hippocampus, neurogenesis carries on throughout postnatal He. The aim of this work was to identify an exogenous control factor of adult neurogenesis. Neurogenesis in the adult dentate gyrus was previously found to be enhanced in vitamin E-deficient rats. The effects of alpha- or beta- tocopherol supplementation on neurogenesis in the adult dentate gyrus were investigated by 5-bromo-2'-deoxyuridine labeling. Tocopherol was found to increase the survival of newborn cells and the total number of Granule cells in the adult rat dentate gyrus. Newborn cells were phenotypically characterized by expression of the immature neuron marker TOAD-64 (turned on after division-64). Therefore tocopherol in high doses possibly increases the number of granule cells in the dentate gyrus by saving newborn cells from death.

引用

页码：170 / 176

页数：7

共 57 条

[31] BLOCKADE OF NMDA RECEPTORS INCREASES CELL-DEATH AND BIRTH IN THE DEVELOPING RAT DENTATE GYRUS [J].

GOULD, E ;

CAMERON, HA ;

MCEWEN, BS .

JOURNAL OF COMPARATIVE NEUROLOGY, 1994, 340 (04) :551-565

[32] Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress [J].

Gould, E ;

Tanapat, P ;

McEwen, BS ;

Flügge, G ;

Fuchs, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (06) :3168-3171

[33] Vitamin E inhibits proliferation of human Tenon's capsule fibroblasts in vitro [J].

Haas, AL ;

Boscoboinik, D ;

Mojon, DS ;

Bohnke, M ;

Azzi, A .

OPHTHALMIC RESEARCH, 1996, 28 (03) :171-175

[34]

Hastings NB, 1999, J COMP NEUROL, V413, P146, DOI 10.1002/(SICI)1096-9861(19991011)413:1<146::AID-CNE10>3.0.CO

[35]

2-B

[36]

Joseph JA, 1998, J NEUROSCI, V18, P8047

[37] NEUROGENESIS IN ADULT RAT - ELECTRON-MICROSCOPIC ANALYSIS OF LIGHT AUTORADIOGRAPHS [J].

KAPLAN, MS ;

HINDS, JW .

SCIENCE, 1977, 197 (4308) :1092-1094

[38]

Kasparek S., 1980, Vitamin E, P7

[39]

Kempermann G, 1998, J NEUROSCI, V18, P3206

[40] More hippocampal neurons in adult mice living in an enriched environment [J].

Kempermann, G ;

Kuhn, HG ;

Gage, FH .

NATURE, 1997, 386 (6624) :493-495

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