Prevention of peroxynitrite-dependent tyrosine nitration and inactivation of alpha(1)-antiproteinase by antibiotics

被引：64

作者：

Whiteman, M ^{[1
]}

Halliwell, B ^{[1
]}

机构：

[1] UNIV LONDON KINGS COLL,NEURODEGENERAT DIS RES CTR,PHARMACOL GRP,LONDON SW3 6LX,ENGLAND

来源：

FREE RADICAL RESEARCH | 1997年 / 26卷 / 01期

关键词：

peroxynitrite; antibiotic; tetracycline; rifamycin; nitric oxide;

D O I：

10.3109/10715769709097783

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Peroxynitrite, formed by reaction of superoxide and nitric oxide, appears to be an important tissue damaging species generated at sites of inflammation. In this paper, we compare the abilities of several antibiotics to protect against peroxynitrite-dependent inactivation of al-antiproteinase, and to inhibit tyrosine nitration by peroxynitrite, in vitro. Tetracycline, minocycline, doxycycline, rifamycin and rifampicin were highly-protective in both assay systems, whereas several other antibiotics tested were not. The possibility that antibiotics could affect tissue injury at sites of inflammation by scavenging peroxynitrite is discussed.

引用

页码：49 / 56

页数：8

共 33 条

[1] BECKMAN JS, 1994, METHOD ENZYMOL, V233, P229
[2] EXTENSIVE NITRATION OF PROTEIN TYROSINES IN HUMAN ATHEROSCLEROSIS DETECTED BY IMMUNOHISTOCHEMISTRY
BECKMANN, JS
YE, YZ
ANDERSON, PG
CHEN, J
ACCAVITTI, MA
TARPEY, MM
WHITE, CR
BECKMAN, JS
[J]. BIOLOGICAL CHEMISTRY HOPPE-SEYLER, 1994, 375 (02): : 81 - 88
[3] INDUCTION AND MECHANISM OF DNA SINGLE-STRAND AND DOUBLE-STRAND BREAKS BY TETRACYCLINE/CU(II) IN THE ABSENCE OF LIGHT
BUSCHFORT, C
WITTE, I
[J]. CARCINOGENESIS, 1994, 15 (12) : 2927 - 2930
[4] PROTECTION BY ANTIBIOTICS AGAINST MYELOPEROXIDASE-DEPENDENT CYTOTOXICITY TO LUNG EPITHELIAL-CELLS INVITRO
CANTIN, A
WOODS, DE
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1993, 91 (01) : 38 - 45
[5] INACTIVATION OF THE ELASTASE INHIBITORY ACTIVITY OF ALPHA-1 ANTITRYPSIN IN FRESH SAMPLES OF SYNOVIAL-FLUID FROM PATIENTS WITH RHEUMATOID-ARTHRITIS
CHIDWICK, K
WINYARD, PG
ZHANG, Z
FARRELL, AJ
BLAKE, DR
[J]. ANNALS OF THE RHEUMATIC DISEASES, 1991, 50 (12) : 915 - 916
[6] NITRIC-OXIDE AND OXYGEN RADICALS - A QUESTION OF BALANCE
DARLEYUSMAR, V
WISEMAN, H
HALLIWELL, B
[J]. FEBS LETTERS, 1995, 369 (2-3) : 131 - 135
[7] OXIDATIVE DAMAGE TO LIPIDS AND ALPHA(1)-ANTIPROTEINASE BY PHENYLBUTAZONE IN THE PRESENCE OF HEME-PROTEINS - PROTECTION BY ASCORBIC-ACID
EVANS, PJ
CECCHINI, R
HALLIWELL, B
[J]. BIOCHEMICAL PHARMACOLOGY, 1992, 44 (05) : 981 - 984
[8] GREENWALD RA, 1992, J RHEUMATOL, V19, P927
[9] GUNTHER MR, 1993, ANTIMICROBIAL AGENTS, V37, P650
[10] Gutteridge J. M. C., 1989, FREE RADICALS BIOL M

← 1 2 3 4 →