Technology challenges in small animal PET imaging

被引：54

作者：

Lecomte, R ^{[1
]}

机构：

[1] Univ Sherbrooke, Sherbrooke, PQ J1K 2R1, Canada

[2] CHUS, CRC, Metab & Funct Imaging Ctr, Sherbrooke, PQ J1K 2R1, Canada

来源：

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT | 2004年 / 527卷 / 1-2期

关键词：

positron emission tomography; small animal imaging; detector technology; scanner performance;

D O I：

10.1016/j.nima.2004.03.113

中图分类号：

TH7 [仪器、仪表];

学科分类号：

0804 ; 080401 ; 081102 ;

摘要：

Positron Emission Tomography (PET) is a non-invasive nuclear imaging modality allowing biochemical processes to be investigated in vivo with sensitivity in the picomolar range. For this reason, PET has the potential to play a major role in the emerging field of molecular imaging by enabling the study of molecular pathways and genetic processes in living animals non-invasively. The challenge is to obtain a spatial resolution that is appropriate for rat and mouse imaging, the preferred animal models for research in biology, while achieving a sensitivity adequate for real-time measurement of rapid dynamic processes in vivo without violating tracer kinetic principles. An overview of the current state of development of dedicated small animal PET scanners is given, and selected applications are reported and discussed with respect to performance and significance to research in biology. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：157 / 165

页数：9

共 77 条

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