CSL-independent Notch signalling: a checkpoint in cell fate decisions during development?

被引：181

作者：

Arias, AM

Zecchini, V

Brennan, K

机构：

[1] Univ Cambridge, Dept Genet, Cambridge CB2 3EH, England

[2] Univ Cambridge, Dept Oncol, Hutchinson MRC Res Ctr, Lab 4 19, Cambridge CB2 2XZ, England

[3] Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2002年 / 12卷 / 05期

关键词：

D O I：

10.1016/S0959-437X(02)00336-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

During development, signalling by members of the Notch family of cell surface receptors plays a widespread role in the assignation of cell fates within the process of lateral inhibition. This function of Notch is mediated by a well-established mechanism that relies on a ligand-induced release of the intracellular domain of Notch (NICD) and the interaction of this fragment with members of the CSL (CBF1, Suppressor of Hairless, Lag-1) family of transcription factors within the nucleus. However, there is increasing evidence that Notch can signal in CSL-independent modes.

引用

页码：524 / 533

页数：10

共 94 条

[61] The Notch1 receptor is cleaved constitutively by a furin-like convertase [J].