CSL-independent Notch signalling: a checkpoint in cell fate decisions during development?

被引:181
作者
Arias, AM
Zecchini, V
Brennan, K
机构
[1] Univ Cambridge, Dept Genet, Cambridge CB2 3EH, England
[2] Univ Cambridge, Dept Oncol, Hutchinson MRC Res Ctr, Lab 4 19, Cambridge CB2 2XZ, England
[3] Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England
关键词
D O I
10.1016/S0959-437X(02)00336-2
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
During development, signalling by members of the Notch family of cell surface receptors plays a widespread role in the assignation of cell fates within the process of lateral inhibition. This function of Notch is mediated by a well-established mechanism that relies on a ligand-induced release of the intracellular domain of Notch (NICD) and the interaction of this fragment with members of the CSL (CBF1, Suppressor of Hairless, Lag-1) family of transcription factors within the nucleus. However, there is increasing evidence that Notch can signal in CSL-independent modes.
引用
收藏
页码:524 / 533
页数:10
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