Synthesis and V-ATPase inhibition of simplified lobatamide analogues

被引：38

作者：

Shen, RC

Lin, CT

Bowman, EJ

Bowman, BJ

Porco, JA

机构：

[1] Boston Univ, Metcalf Ctr Sci & Engn, Dept Chem, Boston, MA 02215 USA

[2] Boston Univ, Metcalf Ctr Sci & Engn, Ctr Streamlined Synth, Boston, MA 02215 USA

[3] Univ Calif Santa Cruz, Sinsheimer Labs, Dept Mol Cell & Dev Biol, Santa Cruz, CA 95064 USA

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 18期

关键词：

D O I：

10.1021/ol026391z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Simplified analogues of the lobatamides have been synthesized and evaluated for inhibition of bovine V-ATPase. The salicylate phenol, enamide NH, and the ortho-substitution of the salicylate ester have been shown to be important for V-ATPase inhibitory activity.

引用

页码：3103 / 3106

页数：4

共 38 条

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