Paralogous Hox genes: Function and regulation

被引：181

作者：

Maconochie, M

Nonchev, S

Morrison, A

Krumlauf, R

机构：

[1] Div. of Developmental Neurobiology, MRC Natl. Inst. for Medical Research, The Ridgeway, London NW7 1AA, Mill Hill

来源：

ANNUAL REVIEW OF GENETICS | 1996年 / 30卷

关键词：

Hox mutant; gene regulation; evolution; development; pattern formation;

D O I：

10.1146/annurev.genet.30.1.529

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The Hox homeobox gene family plays a pivotal role in regulating patterning and axial morphogenesis in vertebrates. Molecular characterization of the four Hox clusters has shown that they are evolutionarily related with respect to sequence, organization, and expression, suggesting they arose by duplication and divergence. Transgenic analysis has clearly demonstrated the functional roles of individual genes in a broad range of embryonic tissues, and in compound mutants has addressed the issues of cooperativity and redundancy. There is an emerging picture of the cis-regulatory elements underlying Hox expression, and for the 3' members of the clusters there is a considerable degree of conservation between paralogous genes with respect to their functional roles and regulatory control.

引用

页码：529 / 556

页数：28

共 141 条

[11] HOMEOTIC GENES AND THE EVOLUTION OF ARTHROPODS AND CHORDATES [J].

CARROLL, SB .

NATURE, 1995, 376 (6540) :479-485

[12] An extradenticle-induced conformational change in a HOX protein overcomes an inhibitory function of the conserved hexapeptide motif [J].

Chan, SK ;

Popperl, H ;

Krumlauf, R ;

Mann, RS .

EMBO JOURNAL, 1996, 15 (10) :2476-2487

[13] THE DNA-BINDING SPECIFICITY OF ULTRABITHORAX IS MODULATED BY COOPERATIVE INTERACTIONS WITH EXTRADENTICLE, ANOTHER HOMEOPROTEIN [J].

CHAN, SK ;

JAFFE, L ;

CAPOVILLA, M ;

BOTAS, J ;

MANN, RS .

CELL, 1994, 78 (04) :603-615

[14] DEVELOPMENTAL DEFECTS OF THE EAR, CRANIAL NERVES AND HINDBRAIN RESULTING FROM TARGETED DISRUPTION OF THE MOUSE HOMEOBOX GENE HOX-1.6 [J].

CHISAKA, O ;

MUSCI, TS ;

CAPECCHI, MR .

NATURE, 1992, 355 (6360) :516-520

[15] REGIONALLY RESTRICTED DEVELOPMENTAL DEFECTS RESULTING FROM TARGETED DISRUPTION OF THE MOUSE HOMEOBOX GENE HOX-1.5 [J].

CHISAKA, O ;

CAPECCHI, MR .

NATURE, 1991, 350 (6318) :473-479

[16] LOCAL-SOURCES OF RETINOIC ACID COINCIDE WITH RETINOID-MEDIATED TRANSGENE ACTIVITY DURING EMBRYONIC-DEVELOPMENT [J].

COLBERT, MC ;

LINNEY, E ;

LAMANTIA, AS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (14) :6572-6576

[17]

CONDIE BG, 1993, DEVELOPMENT, V119, P579

[18] MICE WITH TARGETED DISRUPTIONS IN THE PARALOGOUS GENES HOXA-3 AND HORD-3 REVEAL SYNERGISTIC INTERACTIONS [J].

CONDIE, BG ;

CAPECCHI, MR .

NATURE, 1994, 370 (6487) :304-307

[19]

CONLON RA, 1992, DEVELOPMENT, V116, P357

[20] THE MOUSE SEGMENTATION GENE KR ENCODES A NOVEL BASIC DOMAIN LEUCINE-ZIPPER TRANSCRIPTION FACTOR [J].

CORDES, SP ;

BARSH, GS .

CELL, 1994, 79 (06) :1025-1034

← 1 2 3 4 5 6 7 8 9 10 →