Humoral immunity and long-lived plasma cells

被引：173

作者：

Manz, RA

Arce, S

Cassese, G

Hauser, AE

Hiepe, F

Radbruch, A

机构：

[1] German Arthrit Res Ctr, Dept Humoral Immunol, D-10117 Berlin, Germany

[2] Humboldt Univ, Charite Univ Hosp, Dept Med Rheumatol & Clin Immunol, D-10117 Berlin, Germany

[3] German Arthrit Res Ctr, Dept Cell Biol, D-10117 Berlin, Germany

来源：

CURRENT OPINION IN IMMUNOLOGY | 2002年 / 14卷 / 04期

关键词：

D O I：

10.1016/S0952-7915(02)00356-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A selected fraction of plasmablasts enters the compartment of nondividing, long-lived plasma cells to maintain humoral antibody memory. In accord with a current model for lymphocyte homeostasis, the lifetime of long-lived plasma cells is probably regulated by competition for a limited number of survival niches present in splenic red pulp, bone marrow and inflamed tissue. Plasma cells secreting autoantibodies specific for some, but not all, self-antigens are probably 'allowed' to enter the compartment of long-lived plasma cells and provide anti body-mediated 'autoimmune memory' that is resistant to conventional therapies.

引用

页码：517 / 521

页数：5

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[32] Origin and homing of intestinal IgA antibody-secreting cells [J].