Cytotoxic effects and reversal of multidrug resistance by ibogan and related indole alkaloids

被引：51

作者：

Kam, TS ^{[1
]}

Sim, KM

Pang, HS

Koyano, T

Hayashi, M

Komiyama, K

机构：

[1] Univ Malaya, Dept Chem, Kuala Lumpur 50603, Malaysia

[2] Temko Corp, Nakano Ku, Tokyo 164, Japan

[3] Kitasato Inst, Minato Ku, Tokyo 1088642, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 17期

关键词：

D O I：

10.1016/j.bmcl.2004.06.074

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

A series of indole alkaloids of the ibogan-type was assessed for their cytotoxic effects as well as their potential in reversing MDR in vincristine-resistant KB cells. Of a total of 25 compounds tested, 3(S)-cyanocoronaridine, 3(S)-cyanoisovoacangine, 3(S)-cyanovoacangine, and 10, 11-demethoxychippiine were found to show appreciable cytotoxicity toward KB cells, while coronaridine, heyneanine, 19-epi-heyneanine, dippinine B, and dippinine C, were found to reverse MDR in vincristine-resistant KB cells. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：4487 / 4489

页数：3

共 13 条

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Inhibitors of multidrug resistance to antitumor agents (MDR) [J].