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HPLC separation of antibiotics present in formulated and unformulated samples

被引：105
作者：
Joshi, S [1 ]
机构：
[1] KLDAV Coll, Dept Chem, Roorkee 247667, Uttar Pradesh, India
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2002年 / 28卷 / 05期
关键词：
reviews; HPLC; antibiotics; pharmaceutical analysis; penicillins; cephalosporins; macrolides; tetracyclines; aminoglycosides; quinolones;
D O I：
10.1016/S0731-7085(01)00706-3
中图分类号：
O65 [分析化学];
学科分类号：
070302 [分析化学]; 081704 [应用化学];
摘要：
Analysis of antibiotics in formulated and unformulated samples demand a highly specific and rapid method as many antibiotics (e.g. beta-lactams) have serious stability problems. HPLC techniques can provide a valuable tool for generating highly pure preparations for characterizing the antimicrobial activities. In the present review article, column and mobile phase conditions for the various classes of antibiotics viz. penicillins, cephalosporins, macrolides, tetracyclines, aminoglycosides, quinolones, rifamycins etc. have been presented from April 1998 to November 2000. A brief discussion on chemical structure, spectrum of activity and action mechanism of each class has also been given. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：795 / 809
页数：15
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