Simultaneous Determination of Atenolol and Chlorthalidone in Pharmaceutical Preparations by Capillary-Zone Electrophoresis

被引：17

作者：

Al Azzam, Khaldun ^{[1
]}

Elbashir, Abdalla A. ^{[1
]}

Elbashir, Mohammed A. ^{[1
]}

Saad, Bahruddin ^{[1
]}

Hamid, Shafida Abdul ^{[1
]}

机构：

[1] Univ Sains Malaysia, Sch Chem Sci, George Town 11800, Malaysia

来源：

ANALYTICAL LETTERS | 2009年 / 42卷 / 10期

关键词：

atenolol; capillary zone electrophoresis; chlorthalidone; pharmaceutical preparations; BETA-BLOCKER ATENOLOL; LIQUID-CHROMATOGRAPHY; QUANTITATIVE-DETERMINATION; DOSAGE FORMS; HUMAN-PLASMA; LC-MS; HYDROCHLOROTHIAZIDE; FORMULATIONS; MIXTURES; METOPROLOL;

D O I：

10.1080/00032710902961065

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A capillary zone electrophoresis (CZE) method for the simultaneous determination of the -blocker drugs atenolol and chlorthalidone in pharmaceutical formulations has been developed. The CZE separation was performed under the following conditions: capillary temperature, 25 degrees C; applied voltage, 25kV; 20mM H3PO4-NaOH running buffer (pH 9.0); and detection wavelength, 198nm. Phenobarbital was used as internal standard. The method was validated and showed not only good precision and accuracy but also good robustness. The method has been successfully applied to the simultaneous determination of both atenolol and chlorthalidone in pharmaceutical tablets.

引用

页码：1458 / 1470

页数：13

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