Poly-ε-caprolactone microspheres and nanospheres:: an overview

被引：836

作者：

Sinha, VR ^{[1
]}

Bansal, K ^{[1
]}

Kaushik, R ^{[1
]}

Kumria, R ^{[1
]}

Trehan, A ^{[1
]}

机构：

[1] Panjab Univ, Inst Pharmaceut Sci, Chandigarh 160014, India

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2004年 / 278卷 / 01期

关键词：

poly-epsilon-caprolactone; microsphere; implant;

D O I：

10.1016/j.ijpharm.2004.01.044

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Poly-epsilon-caprol actone (PCL) is a biodegradable, biocompatible and semicrystalline polymer having a very low glass transition temperature. Due to its slow degradation, PCL is ideally suitable for long-term delivery extending over a period of more than one year. This has led to its application in the preparation of different delivery systems in the form of microspheres, nanospheres and implants. Various categories of drugs have been encapsulated in PCL for targeted drug delivery and for controlled drug release. Microspheres of PCL either alone or of PCL copolymers have been prepared to obtain the drug release characteristics. This article reviews the advancements made in PCL-based microspheres and nanospheres with special reference to the method of preparation of these and their suitability in developing effective delivery systems. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：1 / 23

页数：23

共 112 条

[21] Changes in cisplatin delivery due to surface-coated poly (lactic acid)-poly(ε-caprolactone) microspheres [J].

Chandy, T ;

Wilson, RF ;

Rao, GHR ;

Das, GS .

JOURNAL OF BIOMATERIALS APPLICATIONS, 2002, 16 (04) :275-291

[22] DISSOLUTION CHARACTERISTICS OF POLYCAPROLACTONE-POLYLACTIDE MICROSPHERES OF CHLORPROMAZINE [J].

CHANG, RK ;

PRICE, JC ;

WHITWORTH, CW .

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1986, 12 (14) :2355-2380

[23] ENHANCEMENT OF DISSOLUTION RATE BY INCORPORATION INTO A WATER INSOLUBLE POLYMER, POLYCAPROLACTONE [J].

CHANG, RK ;

PRICE, JC ;

WHITWORTH, CW .

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1987, 13 (02) :249-256

[24] CONTROL OF DRUG RELEASE RATE BY USE OF MIXTURES OF POLYCAPROLACTONE AND CELLULOSE-ACETATE BUTYRATE POLYMERS [J].

CHANG, RK ;

PRICE, J ;

WHITWORTH, CW .

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1987, 13 (06) :1119-1135

[25] Biodegradable poly(ε-caprolactone) nanoparticles for tumor-targeted delivery of tamoxifen [J].

Chawla, JS ;

Amiji, MM .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2002, 249 (1-2) :127-138

[26]

Chen DR, 2000, POLYM INT, V49, P269, DOI 10.1002/(SICI)1097-0126(200003)49:3<269::AID-PI358>3.0.CO

[27]

2-Z

[28]

Couvreur P., 1982, U. S. Patent, Patent No. [4,329,332, 4329332, 4329332 A]

[29]

Das GS, 2000, DRUG DELIV, V7, P129

[30]

deChasteigner S, 1996, DRUG DEVELOP RES, V38, P116, DOI 10.1002/(SICI)1098-2299(199606)38:2&lt

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