Fusidienol A: A novel Ras farnesyl-protein transferase inhibitor from Phoma sp.

被引：24

作者：

Singh, SB ^{[1
]}

Ball, RG ^{[1
]}

Zink, DL ^{[1
]}

Monaghan, RL ^{[1
]}

Polishook, JD ^{[1
]}

Sanchez, M ^{[1
]}

Pelaez, F ^{[1
]}

Silverman, KC ^{[1
]}

Lingham, RB ^{[1
]}

机构：

[1] MERCK SHARP & DOHME ESPANA SA,CTR INVEST BASICA,MADRID 28027,SPAIN

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1997年 / 62卷 / 21期

关键词：

D O I：

10.1021/jo9708304

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Human tumorogenesis is a multifunctional process encompassing changes in the activity of multiple genes and their cognate proteins. One such gene product is Ras protein. The lability of fusidienol in organic solvents precluded its crystallization for X-ray crystallographic studies. In contrast, fusidienol A is stable in organic solvents. The major difference between the two compounds is the presence of an enylic hydroxymethyl group in fusidienol that may be responsible for the instability. The methoxy protons, as expected, gave correlations only to the ester carbonyl. Like fusidienol, two- and three-bond HMBC correlations of H-11 and H-13 to the respective carbons helped in assembling the oxepin ring in the left hand side of the molecule. © 1997 American Chemical Society.

引用

页码：7485 / 7488

页数：4

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