The role of BTB domain-containing zinc finger proteins in T cell development and function

被引：48

作者：

Bilic, Ivan ^{[1
]}

Ellmeier, Wilfried ^{[1
]}

机构：

[1] Med Univ Vienna, Inst Immunol, A-1090 Vienna, Austria

来源：

IMMUNOLOGY LETTERS | 2007年 / 108卷 / 01期

基金：

奥地利科学基金会;

关键词：

T cell development; T cell subsets; BTB domain; zinc finger; gene expression; transcriptional regulation; gene knockout;

D O I：

10.1016/j.imlet.2006.09.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cell fate specifications during T lymphocyte differentiation result from the orchestrated expression of developmentally regulated genes. Furthermore, epigenetic processes that result in a heritable chromatin structure are required for the maintenance of gene expression programs within cells. More and more is known about the basic mechanisms of T cell development and their diversification into various peripheral T cell subsets. Recent research has begun to provide insight into the interactive network of transcription factors as critical regulators of T lymphocyte differentiation. In the past years several members of the BTB domain-containing family of zinc finger proteins (BTB-ZF) have been described to be important for the development and function of hematopoietic cells, and also to contribute to malignant hematopoiesis. This review will provide a brief overview about the role of BTB-ZF proteins during thymocyte development and T cell function. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：1 / 9

页数：9

共 87 条

[1] Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain [J].

Ahmad, KF ;

Melnick, A ;

Lax, S ;

Bouchard, D ;

Liu, J ;

Kiang, CL ;

Mayer, S ;

Takahashi, S ;

Licht, JD ;

Privé, GG .

MOLECULAR CELL, 2003, 12 (06) :1551-1564

[2] Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR [J].

Bilic, I ;

Koesters, C ;

Unger, B ;

Sekimata, M ;

Hertweck, A ;

Maschek, R ;

Wilson, CB ;

Ellmeier, W .

NATURE IMMUNOLOGY, 2006, 7 (04) :392-400

[3] Ensembl 2006 [J].

Birney, E. ;

Andrews, D. ;

Caccamo, M. ;

Chen, Y. ;

Clarke, L. ;

Coates, G. ;

Cox, T. ;

Cunningham, F. ;

Curwen, V. ;

Cutts, T. ;

Down, T. ;

Durbin, R. ;

Fernandez-Suarez, X. M. ;

Flicek, P. ;

Graf, S. ;

Hammond, M. ;

Herrero, J. ;

Howe, K. ;

Iyer, V. ;

Jekosch, K. ;

Kahari, A. ;

Kasprzyk, A. ;

Keefe, D. ;

Kokocinski, F. ;

Kulesha, E. ;

London, D. ;

Longden, I. ;

Melsopp, C. ;

Meidl, P. ;

Overduin, B. ;

Parker, A. ;

Proctor, G. ;

Prlic, A. ;

Rae, M. ;

Rios, D. ;

Redmond, S. ;

Schuster, M. ;

Sealy, I. ;

Searle, S. ;

Severin, J. ;

Slater, G. ;

Smedley, D. ;

Smith, J. ;

Stabenau, A. ;

Stalker, J. ;

Trevanion, S. ;

Ureta-Vidal, A. ;

Vogel, J. ;

White, S. ;

Woodwark, C. .

NUCLEIC ACIDS RESEARCH, 2006, 34 :D556-D561

[4] CD4/CD8-lineage differentiation in the thymus: From nuclear effectors to membrane signals [J].

Bosselut, R .

NATURE REVIEWS IMMUNOLOGY, 2004, 4 (07) :529-540

[5] Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production [J].

Breitfeld, D ;

Ohl, L ;

Kremmer, E ;

Ellwart, J ;

Sallusto, F ;

Lipp, M ;

Förster, R .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (11) :1545-1551

[6] BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor [J].

Chang, CC ;

Ye, BH ;

Chaganti, RSK ;

DallaFavera, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (14) :6947-6952

[7] Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes [J].

Chi, TH ;

Wan, M ;

Zhao, KJ ;

Taniuchi, I ;

Chen, L ;

Littman, DR ;

Crabtree, GR .

NATURE, 2002, 418 (6894) :195-199

[8] Homeostasis-stimulated proliferation drives naive T cells to differentiate directly into memory T cells [J].

Cho, BK ;

Rao, VP ;

Ge, Q ;

Eisen, HN ;

Chen, JZ .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (04) :549-556

[9] T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells [J].

Chtanova, T ;

Tangye, SG ;

Newton, R ;

Frank, N ;

Hodge, MR ;

Rolph, MS ;

Mackay, CR .

JOURNAL OF IMMUNOLOGY, 2004, 173 (01) :68-78

[10] All in the family: the BTB/POZ, KRAB, and SCAN domains [J].

Collins, T ;

Stone, JR ;

Williams, AJ .

MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (11) :3609-3615

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