Wnt signaling: Ig-Norrin the dogma

被引：21

作者：

Clevers, H ^{[1
]}

机构：

[1] Hubrecht Lab, NL-3584 CT Utrecht, Netherlands

来源：

CURRENT BIOLOGY | 2004年 / 14卷 / 11期

关键词：

D O I：

10.1016/j.cub.2004.05.039

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Secreted Wnt proteins trigger the intracellular Wnt signaling cascade upon engagement of dedicated Frizzled-Lrp receptor complexes. Unexpectedly, a non-Wnt ligand for this receptor complex has now been discovered. This novel ligand, Norrin, is mutated in the hereditary ocular Norrie syndrome.

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页码：R436 / R437

页数：2

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