共 43 条
Apolipoprotein E in cerebrospinal fluid from patients with Alzheimer's disease and other forms of dementia is reduced but without any correlation to the apoE4 isoform
被引:50
作者:

Landen, M
论文数: 0 引用数: 0
h-index: 0
机构:
GOTHENBURG UNIV, DEPT PSYCHIAT & NEUROCHEM, S-41124 GOTHENBURG, SWEDEN GOTHENBURG UNIV, DEPT PSYCHIAT & NEUROCHEM, S-41124 GOTHENBURG, SWEDEN

Hesse, C
论文数: 0 引用数: 0
h-index: 0
机构:
GOTHENBURG UNIV, DEPT PSYCHIAT & NEUROCHEM, S-41124 GOTHENBURG, SWEDEN GOTHENBURG UNIV, DEPT PSYCHIAT & NEUROCHEM, S-41124 GOTHENBURG, SWEDEN

Fredman, P
论文数: 0 引用数: 0
h-index: 0
机构:
GOTHENBURG UNIV, DEPT PSYCHIAT & NEUROCHEM, S-41124 GOTHENBURG, SWEDEN GOTHENBURG UNIV, DEPT PSYCHIAT & NEUROCHEM, S-41124 GOTHENBURG, SWEDEN

Regland, B
论文数: 0 引用数: 0
h-index: 0
机构:
GOTHENBURG UNIV, DEPT PSYCHIAT & NEUROCHEM, S-41124 GOTHENBURG, SWEDEN GOTHENBURG UNIV, DEPT PSYCHIAT & NEUROCHEM, S-41124 GOTHENBURG, SWEDEN

Wallin, A
论文数: 0 引用数: 0
h-index: 0
机构:
GOTHENBURG UNIV, DEPT PSYCHIAT & NEUROCHEM, S-41124 GOTHENBURG, SWEDEN GOTHENBURG UNIV, DEPT PSYCHIAT & NEUROCHEM, S-41124 GOTHENBURG, SWEDEN

Blennow, K
论文数: 0 引用数: 0
h-index: 0
机构:
GOTHENBURG UNIV, DEPT PSYCHIAT & NEUROCHEM, S-41124 GOTHENBURG, SWEDEN GOTHENBURG UNIV, DEPT PSYCHIAT & NEUROCHEM, S-41124 GOTHENBURG, SWEDEN
机构:
[1] GOTHENBURG UNIV, DEPT PSYCHIAT & NEUROCHEM, S-41124 GOTHENBURG, SWEDEN
来源:
DEMENTIA
|
1996年
/
7卷
/
05期
关键词:
apolipoprotein E;
isoforms;
Alzheimer's disease;
vascular dementia;
frontal lobe dementia;
cerebrospinal fluid;
D O I:
10.1159/000106892
中图分类号:
R74 [神经病学与精神病学];
学科分类号:
摘要:
Apolipoprotein E (apoE) has been suggested to play a role in regenerative processes in the brain after trauma, and also in the pathogenesis of Alzheimer's disease (AD). We examined cerebrospinal fluid (CSF) apoE in a material consisting of 23 patients with early-onset AD (EAD), 31 with late-onset AD CLAD), 16 with frontal-lobe dementia (FLD), 25 with vascular dementia (VAD) and 25 controls. CSF-apoE was decreased in all of EAD (1.8 +/- 1.1 mg/l; p < 0.0005), LAD (2.5 +/- 0.9 mg/l; p < 0.0005), VAD (2.3 +/- 1.4 mg/l; p < 0.0005) and FLD (3.0 +/- 1.3 mg/l; p < 0.05) compared to the control group (5.7 +/- 4.0 mg/l). Since apoE4 has been found to bind to beta/A4-amyloid, and AD patients homozygous for apoE4 to have higher number of senile plaques than apoE3 homozygotes, we also examined the relation between CSF-apoE and apoE alleles. However, CSF-apoE did not significantly differ between patients with different apoE isoforms. Our findings support that apoE is involved in the pathogenesis of dementia disorders, both degenerative and vascular, but the CSF-apoE level is not influenced by the apoE isoforms. CSF-apoE may be used as an unspecific marker for neurodegenerative disorders, but not in purpose of differential diagnostics between different dementia disorders.
引用
收藏
页码:273 / 278
页数:6
相关论文
共 43 条
[1]
APO-E-ALLELE FREQUENCIES IN ALZHEIMERS-DISEASE, LEWY BODY DEMENTIA, ALZHEIMERS-DISEASE WITH CEREBROVASCULAR-DISEASE AND VASCULAR DEMENTIA
[J].
BETARD, C
;
ROBITAILLE, Y
;
GEE, M
;
TIBERGHIEN, D
;
LARRIVEE, D
;
ROY, P
;
MORTIMER, JA
;
GAUVREAU, D
.
NEUROREPORT,
1994, 5 (15)
:1893-1896

BETARD, C
论文数: 0 引用数: 0
h-index: 0
机构:
VET ADM MED CTR,CTR GERIATR RES EDUC & CLIN,MINNEAPOLIS,MN 55417 VET ADM MED CTR,CTR GERIATR RES EDUC & CLIN,MINNEAPOLIS,MN 55417

ROBITAILLE, Y
论文数: 0 引用数: 0
h-index: 0
机构:
VET ADM MED CTR,CTR GERIATR RES EDUC & CLIN,MINNEAPOLIS,MN 55417 VET ADM MED CTR,CTR GERIATR RES EDUC & CLIN,MINNEAPOLIS,MN 55417

GEE, M
论文数: 0 引用数: 0
h-index: 0
机构:
VET ADM MED CTR,CTR GERIATR RES EDUC & CLIN,MINNEAPOLIS,MN 55417 VET ADM MED CTR,CTR GERIATR RES EDUC & CLIN,MINNEAPOLIS,MN 55417

TIBERGHIEN, D
论文数: 0 引用数: 0
h-index: 0
机构:
VET ADM MED CTR,CTR GERIATR RES EDUC & CLIN,MINNEAPOLIS,MN 55417 VET ADM MED CTR,CTR GERIATR RES EDUC & CLIN,MINNEAPOLIS,MN 55417

LARRIVEE, D
论文数: 0 引用数: 0
h-index: 0
机构:
VET ADM MED CTR,CTR GERIATR RES EDUC & CLIN,MINNEAPOLIS,MN 55417 VET ADM MED CTR,CTR GERIATR RES EDUC & CLIN,MINNEAPOLIS,MN 55417

ROY, P
论文数: 0 引用数: 0
h-index: 0
机构:
VET ADM MED CTR,CTR GERIATR RES EDUC & CLIN,MINNEAPOLIS,MN 55417 VET ADM MED CTR,CTR GERIATR RES EDUC & CLIN,MINNEAPOLIS,MN 55417

MORTIMER, JA
论文数: 0 引用数: 0
h-index: 0
机构:
VET ADM MED CTR,CTR GERIATR RES EDUC & CLIN,MINNEAPOLIS,MN 55417 VET ADM MED CTR,CTR GERIATR RES EDUC & CLIN,MINNEAPOLIS,MN 55417

GAUVREAU, D
论文数: 0 引用数: 0
h-index: 0
机构:
VET ADM MED CTR,CTR GERIATR RES EDUC & CLIN,MINNEAPOLIS,MN 55417 VET ADM MED CTR,CTR GERIATR RES EDUC & CLIN,MINNEAPOLIS,MN 55417
[2]
PROTEIN ANALYSES IN CEREBROSPINAL-FLUID .1. INFLUENCE OF CONCENTRATION GRADIENTS FOR PROTEINS ON CEREBROSPINAL-FLUID SERUM-ALBUMIN RATIO
[J].
BLENNOW, K
;
FREDMAN, P
;
WALLIN, A
;
GOTTFRIES, CG
;
LANGSTROM, G
;
SVENNERHOLM, L
.
EUROPEAN NEUROLOGY,
1993, 33 (02)
:126-128

BLENNOW, K
论文数: 0 引用数: 0
h-index: 0
机构: Department of Psychiatry and Neurochemistry, University of Goteborg, Molndal Hospital, Mölndal

FREDMAN, P
论文数: 0 引用数: 0
h-index: 0
机构: Department of Psychiatry and Neurochemistry, University of Goteborg, Molndal Hospital, Mölndal

WALLIN, A
论文数: 0 引用数: 0
h-index: 0
机构: Department of Psychiatry and Neurochemistry, University of Goteborg, Molndal Hospital, Mölndal

GOTTFRIES, CG
论文数: 0 引用数: 0
h-index: 0
机构: Department of Psychiatry and Neurochemistry, University of Goteborg, Molndal Hospital, Mölndal

LANGSTROM, G
论文数: 0 引用数: 0
h-index: 0
机构: Department of Psychiatry and Neurochemistry, University of Goteborg, Molndal Hospital, Mölndal

SVENNERHOLM, L
论文数: 0 引用数: 0
h-index: 0
机构: Department of Psychiatry and Neurochemistry, University of Goteborg, Molndal Hospital, Mölndal
[3]
CEREBROSPINAL-FLUID APOLIPOPROTEIN-E IS REDUCED IN ALZHEIMERS-DISEASE
[J].
BLENNOW, K
;
HESSE, C
;
FREDMAN, P
.
NEUROREPORT,
1994, 5 (18)
:2534-2536

BLENNOW, K
论文数: 0 引用数: 0
h-index: 0
机构: Department of Clinical Neuroscience, Section of Psychiatry and Neurochemistry, University of GÖteborg, Molndal

HESSE, C
论文数: 0 引用数: 0
h-index: 0
机构: Department of Clinical Neuroscience, Section of Psychiatry and Neurochemistry, University of GÖteborg, Molndal

FREDMAN, P
论文数: 0 引用数: 0
h-index: 0
机构: Department of Clinical Neuroscience, Section of Psychiatry and Neurochemistry, University of GÖteborg, Molndal
[4]
APOLIPOPROTEIN-E ASSOCIATED WITH ASTROCYTIC GLIA OF THE CENTRAL NERVOUS-SYSTEM AND WITH NONMYELINATING GLIA OF THE PERIPHERAL NERVOUS-SYSTEM
[J].
BOYLES, JK
;
PITAS, RE
;
WILSON, E
;
MAHLEY, RW
;
TAYLOR, JM
.
JOURNAL OF CLINICAL INVESTIGATION,
1985, 76 (04)
:1501-1513

BOYLES, JK
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF SAN FRANCISCO,DEPT PATHOL,SAN FRANCISCO,CA 94140

PITAS, RE
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF SAN FRANCISCO,DEPT PATHOL,SAN FRANCISCO,CA 94140

WILSON, E
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF SAN FRANCISCO,DEPT PATHOL,SAN FRANCISCO,CA 94140

MAHLEY, RW
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF SAN FRANCISCO,DEPT PATHOL,SAN FRANCISCO,CA 94140

TAYLOR, JM
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF SAN FRANCISCO,DEPT PATHOL,SAN FRANCISCO,CA 94140
[5]
A ROLE FOR APOLIPOPROTEIN-E, APOLIPOPROTEIN-A-I, AND LOW-DENSITY LIPOPROTEIN RECEPTORS IN CHOLESTEROL TRANSPORT DURING REGENERATION AND REMYELINATION OF THE RAT SCIATIC-NERVE
[J].
BOYLES, JK
;
ZOELLNER, CD
;
ANDERSON, LJ
;
KOSIK, LM
;
PITAS, RE
;
WEISGRABER, KH
;
HUI, DY
;
MAHLEY, RW
;
GEBICKEHAERTER, PJ
;
IGNATIUS, MJ
;
SHOOTER, EM
.
JOURNAL OF CLINICAL INVESTIGATION,
1989, 83 (03)
:1015-1031

BOYLES, JK
论文数: 0 引用数: 0
h-index: 0
机构: STANFORD UNIV,DEPT NEUROBIOL,STANFORD,CA 94305

ZOELLNER, CD
论文数: 0 引用数: 0
h-index: 0
机构: STANFORD UNIV,DEPT NEUROBIOL,STANFORD,CA 94305

ANDERSON, LJ
论文数: 0 引用数: 0
h-index: 0
机构: STANFORD UNIV,DEPT NEUROBIOL,STANFORD,CA 94305

KOSIK, LM
论文数: 0 引用数: 0
h-index: 0
机构: STANFORD UNIV,DEPT NEUROBIOL,STANFORD,CA 94305

PITAS, RE
论文数: 0 引用数: 0
h-index: 0
机构: STANFORD UNIV,DEPT NEUROBIOL,STANFORD,CA 94305

WEISGRABER, KH
论文数: 0 引用数: 0
h-index: 0
机构: STANFORD UNIV,DEPT NEUROBIOL,STANFORD,CA 94305

HUI, DY
论文数: 0 引用数: 0
h-index: 0
机构: STANFORD UNIV,DEPT NEUROBIOL,STANFORD,CA 94305

MAHLEY, RW
论文数: 0 引用数: 0
h-index: 0
机构: STANFORD UNIV,DEPT NEUROBIOL,STANFORD,CA 94305

GEBICKEHAERTER, PJ
论文数: 0 引用数: 0
h-index: 0
机构: STANFORD UNIV,DEPT NEUROBIOL,STANFORD,CA 94305

IGNATIUS, MJ
论文数: 0 引用数: 0
h-index: 0
机构: STANFORD UNIV,DEPT NEUROBIOL,STANFORD,CA 94305

SHOOTER, EM
论文数: 0 引用数: 0
h-index: 0
机构: STANFORD UNIV,DEPT NEUROBIOL,STANFORD,CA 94305
[6]
CLINICAL RELEVANCE OF THE QUANTIFICATION OF APOLIPOPROTEIN-E IN CEREBROSPINAL-FLUID
[J].
CARLSSON, J
;
ARMSTRONG, VW
;
REIBER, H
;
FELGENHAUER, K
;
SEIDEL, D
.
CLINICA CHIMICA ACTA,
1991, 196 (2-3)
:167-176

CARLSSON, J
论文数: 0 引用数: 0
h-index: 0
机构: CLIN GROSSHADERN,DEPT CLIN CHEM,MUNICH,GERMANY

ARMSTRONG, VW
论文数: 0 引用数: 0
h-index: 0
机构: CLIN GROSSHADERN,DEPT CLIN CHEM,MUNICH,GERMANY

REIBER, H
论文数: 0 引用数: 0
h-index: 0
机构: CLIN GROSSHADERN,DEPT CLIN CHEM,MUNICH,GERMANY

FELGENHAUER, K
论文数: 0 引用数: 0
h-index: 0
机构: CLIN GROSSHADERN,DEPT CLIN CHEM,MUNICH,GERMANY

SEIDEL, D
论文数: 0 引用数: 0
h-index: 0
机构: CLIN GROSSHADERN,DEPT CLIN CHEM,MUNICH,GERMANY
[7]
GENE DOSE OF APOLIPOPROTEIN-E TYPE-4 ALLELE AND THE RISK OF ALZHEIMERS-DISEASE IN LATE-ONSET FAMILIES
[J].
CORDER, EH
;
SAUNDERS, AM
;
STRITTMATTER, WJ
;
SCHMECHEL, DE
;
GASKELL, PC
;
SMALL, GW
;
ROSES, AD
;
HAINES, JL
;
PERICAKVANCE, MA
.
SCIENCE,
1993, 261 (5123)
:921-923

CORDER, EH
论文数: 0 引用数: 0
h-index: 0
机构: DUKE UNIV,MED CTR,JOSEPH & KATHLEEN BRYAN ALZHEIMERS DIS RES CTR,DEPT MED,DURHAM,NC 27710

SAUNDERS, AM
论文数: 0 引用数: 0
h-index: 0
机构: DUKE UNIV,MED CTR,JOSEPH & KATHLEEN BRYAN ALZHEIMERS DIS RES CTR,DEPT MED,DURHAM,NC 27710

STRITTMATTER, WJ
论文数: 0 引用数: 0
h-index: 0
机构: DUKE UNIV,MED CTR,JOSEPH & KATHLEEN BRYAN ALZHEIMERS DIS RES CTR,DEPT MED,DURHAM,NC 27710

SCHMECHEL, DE
论文数: 0 引用数: 0
h-index: 0
机构: DUKE UNIV,MED CTR,JOSEPH & KATHLEEN BRYAN ALZHEIMERS DIS RES CTR,DEPT MED,DURHAM,NC 27710

GASKELL, PC
论文数: 0 引用数: 0
h-index: 0
机构: DUKE UNIV,MED CTR,JOSEPH & KATHLEEN BRYAN ALZHEIMERS DIS RES CTR,DEPT MED,DURHAM,NC 27710

SMALL, GW
论文数: 0 引用数: 0
h-index: 0
机构: DUKE UNIV,MED CTR,JOSEPH & KATHLEEN BRYAN ALZHEIMERS DIS RES CTR,DEPT MED,DURHAM,NC 27710

ROSES, AD
论文数: 0 引用数: 0
h-index: 0
机构: DUKE UNIV,MED CTR,JOSEPH & KATHLEEN BRYAN ALZHEIMERS DIS RES CTR,DEPT MED,DURHAM,NC 27710

HAINES, JL
论文数: 0 引用数: 0
h-index: 0
机构: DUKE UNIV,MED CTR,JOSEPH & KATHLEEN BRYAN ALZHEIMERS DIS RES CTR,DEPT MED,DURHAM,NC 27710

PERICAKVANCE, MA
论文数: 0 引用数: 0
h-index: 0
机构: DUKE UNIV,MED CTR,JOSEPH & KATHLEEN BRYAN ALZHEIMERS DIS RES CTR,DEPT MED,DURHAM,NC 27710
[8]
MINI-MENTAL STATE - PRACTICAL METHOD FOR GRADING COGNITIVE STATE OF PATIENTS FOR CLINICIAN
[J].
FOLSTEIN, MF
;
FOLSTEIN, SE
;
MCHUGH, PR
.
JOURNAL OF PSYCHIATRIC RESEARCH,
1975, 12 (03)
:189-198

FOLSTEIN, MF
论文数: 0 引用数: 0
h-index: 0
机构: UNIV OREGON,MED SCH,DEPT PSYCHIAT,PORTLAND,OR 97201

FOLSTEIN, SE
论文数: 0 引用数: 0
h-index: 0
机构: UNIV OREGON,MED SCH,DEPT PSYCHIAT,PORTLAND,OR 97201

MCHUGH, PR
论文数: 0 引用数: 0
h-index: 0
机构: UNIV OREGON,MED SCH,DEPT PSYCHIAT,PORTLAND,OR 97201
[9]
APOLIPOPROTEIN-E EPSILON-4 ALLELE FREQUENCY IN VASCULAR DEMENTIA AND ALZHEIMERS-DISEASE
[J].
FRISONI, GB
;
GEROLDI, C
;
BIANCHETTI, A
;
TRABUCCHI, M
;
GOVONI, S
;
FRANCESCHINI, G
;
CALABRESI, L
.
STROKE,
1994, 25 (08)
:1703-1703

FRISONI, GB
论文数: 0 引用数: 0
h-index: 0
机构: GERIATR RES GRP,BRESCIA,ITALY

GEROLDI, C
论文数: 0 引用数: 0
h-index: 0
机构: GERIATR RES GRP,BRESCIA,ITALY

BIANCHETTI, A
论文数: 0 引用数: 0
h-index: 0
机构: GERIATR RES GRP,BRESCIA,ITALY

TRABUCCHI, M
论文数: 0 引用数: 0
h-index: 0
机构: GERIATR RES GRP,BRESCIA,ITALY

GOVONI, S
论文数: 0 引用数: 0
h-index: 0
机构: GERIATR RES GRP,BRESCIA,ITALY

论文数: 引用数:
h-index:
机构:

CALABRESI, L
论文数: 0 引用数: 0
h-index: 0
机构: GERIATR RES GRP,BRESCIA,ITALY
[10]
SENILE DEMENTIA OF THE LEWY BODY TYPE HAS AN APOLIPOPROTEIN-E EPSILON-4 ALLELE FREQUENCY INTERMEDIATE BETWEEN CONTROLS AND ALZHEIMERS-DISEASE
[J].
HARDY, J
;
CROOK, R
;
PRIHAR, G
;
ROBERTS, G
;
RAGHAVAN, R
;
PERRY, R
.
NEUROSCIENCE LETTERS,
1994, 182 (01)
:1-2

HARDY, J
论文数: 0 引用数: 0
h-index: 0
机构: UNIV S FLORIDA,DEPT PHARMACOL,SUNCOAST ALZHEIMERS DIS LABS,TAMPA,FL 33613

CROOK, R
论文数: 0 引用数: 0
h-index: 0
机构: UNIV S FLORIDA,DEPT PHARMACOL,SUNCOAST ALZHEIMERS DIS LABS,TAMPA,FL 33613

PRIHAR, G
论文数: 0 引用数: 0
h-index: 0
机构: UNIV S FLORIDA,DEPT PHARMACOL,SUNCOAST ALZHEIMERS DIS LABS,TAMPA,FL 33613

ROBERTS, G
论文数: 0 引用数: 0
h-index: 0
机构: UNIV S FLORIDA,DEPT PHARMACOL,SUNCOAST ALZHEIMERS DIS LABS,TAMPA,FL 33613

RAGHAVAN, R
论文数: 0 引用数: 0
h-index: 0
机构: UNIV S FLORIDA,DEPT PHARMACOL,SUNCOAST ALZHEIMERS DIS LABS,TAMPA,FL 33613

PERRY, R
论文数: 0 引用数: 0
h-index: 0
机构: UNIV S FLORIDA,DEPT PHARMACOL,SUNCOAST ALZHEIMERS DIS LABS,TAMPA,FL 33613