Lymphocyte kinetics in health and disease

被引：23

作者：

Asquith, Becca ^{[2
]}

Borghans, Jose A. M. ^{[1
,3
]}

Ganusov, Vitaly V. ^{[1
,4
,6
,7
]}

Macallan, Derek C. ^{[5
]}

机构：

[1] Univ Utrecht, NL-3584 CH Utrecht, Netherlands

[2] Univ London Imperial Coll Sci Technol & Med, Wright Fleming Inst, Dept Immunol, London W2 1PG, England

[3] Univ Med Ctr Utrecht, Dept Immunol, NL-3584 EA Utrecht, Netherlands

[4] Los Alamos Natl Lab, Los Alamos, NM 87545 USA

[5] Univ London, Div Cellular & Mol Med, Ctr Infect, London SW17 0RE, England

[6] Inst Biophys, Krasnoyarsk 660036, Russia

[7] Krasnoyarsk Sci Ctr, Krasnoyarsk 660036, Russia

来源：

TRENDS IN IMMUNOLOGY | 2009年 / 30卷 / 04期

基金：

英国惠康基金; 英国工程与自然科学研究理事会; 英国医学研究理事会;

关键词：

SIMIAN IMMUNODEFICIENCY VIRUS; HIV-INFECTED PATIENTS; T-CELL KINETICS; IN-VIVO; RAPID TURNOVER; IMMUNOLOGICAL MEMORY; BONE-MARROW; LIFE-SPAN; B-CELLS; LEUKEMIA;

D O I：

10.1016/j.it.2009.01.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Quantitative understanding of immunology requires the development of experimental and mathematical techniques for estimation of rates of division and death of lymphocytes under different conditions. Here, we review the advantages and limitations of several labelling methods that are currently used to quantify turnover of lymphocytes in vivo. In addition to highlighting insights into lymphocyte kinetics which have recently been gained thanks to the development of novel techniques, we discuss important directions for future experimental and theoretical work in the field of lymphocyte turnover.

引用

页码：182 / 189

页数：8

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[1]

Opinion - Will telomere erosion lead to a loss of T-cell memory? [J].