The cellular response to general and programmed DNA double strand breaks

被引：234

作者：

Bassing, CH

Alt, FW ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Genet, CBR Inst Biomed Res,Childrens Hosp, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Genet, Howard Hughes Med Inst,Childrens Hosp, Boston, MA 02115 USA

来源：

DNA REPAIR | 2004年 / 3卷 / 8-9期

基金：

美国国家卫生研究院;

关键词：

cellular response; DNA double strand breaks; eukaryotic cells;

D O I：

10.1016/j.dnarep.2004.06.001

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

DNA double strand breaks (DSBs) are among the most dangerous lesions that can occur in the genome of eukaryotic cells. Proper repair of chromosomal DSBs is critical for maintaining cellular viability and genomic integrity and, in multi-cellular organisms, for suppression of tumorigenesis. Thus, eukaryotic cells have evolved specialized and redundant molecular mechanisms to sense, respond to, and repair DSBs. in this chapter, we provide an overview of the progress that has been made over the last decade in elucidating the identity and function of components that participate in the cellular response to chromosomal DSBs. Then, we discuss, in more depth, the response to DSBs that occur in the context of the V(D)J recombination and IgH class switch recombination reactions that occur in cells of the lymphocyte lineage. (C) 2004 Elsevier B.V. All rights reserved.

引用

收藏

页码：781 / 796

页数：16

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