Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond

被引：423

作者：

Ghofrani, Hossein A.

Osterloh, Ian H.

Grimminger, Friedrich

机构：

[1] Univ Hosp Giessen & Marburg GmbH, Dept Internal Med, Med Clin 2 5, D-35392 Giessen, Germany

[2] Pfizer Ltd, Sandwich CT13 9NJ, Kent, England

来源：

NATURE REVIEWS DRUG DISCOVERY | 2006年 / 5卷 / 08期

关键词：

D O I：

10.1038/nrd2030

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In less than 20 years, the first selective type 5 phosphodiesterase inhibitor, sildenafil, has evolved from a potential anti-angina drug to an on-demand oral treatment for erectile dysfunction ( Viagra), and more recently to a new orally active treatment for pulmonary hypertension (Revatio). Here we describe the key milestones in the development of sildenafil for these diverse medical conditions, discuss the advances in science and clinical medicine that have accompanied this journey and consider possible future indications for this versatile drug.

引用

收藏

页码：689 / 702

页数：14

相关论文

共 201 条

[91] Regulation of pulmonary circulation by alveolar oxygen tension via airway nitric oxide [J].

Ide, H ;

Nakano, H ;

Ogasa, T ;

Osanai, S ;

Kikuchi, K ;

Iwamoto, J .

JOURNAL OF APPLIED PHYSIOLOGY, 1999, 87 (05) :1629-1636

[92] NITRIC-OXIDE AND CYCLIC-GMP FORMATION UPON ELECTRICAL-FIELD STIMULATION CAUSE RELAXATION OF CORPUS CAVERNOSUM SMOOTH-MUSCLE [J].

IGNARRO, LJ ;

BUSH, PA ;

BUGA, GM ;

WOOD, KS ;

FUKUTO, JM ;

RAJFER, J .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1990, 170 (02) :843-850

[93] Type V phosphodiesterase expression in cerebral arteries with vasospasm after subarachnoid hemorrhage in a canine model [J].

Inoha, S ;

Inamura, T ;

Ikezaki, K ;

Nakamizo, A ;

Amano, T ;

Fukui, M .

NEUROLOGICAL RESEARCH, 2002, 24 (06) :607-612

[94] Regional distribution of human cerebral vascular mean transit time measured by positron emission tomography [J].

Ito, H ;

Kanno, I ;

Takahashi, K ;

Ibaraki, M ;

Miura, S .

NEUROIMAGE, 2003, 19 (03) :1163-1169

[95] A combination of oral sildenafil and beraprost ameliorates pulmonary hypertension in rats [J].

Itoh, T ;

Nagaya, N ;

Fujii, T ;

Iwase, T ;

Nakanishi, N ;

Hamada, K ;

Kangawa, K ;

Kimura, H .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2004, 169 (01) :34-38

[96] Past, present, and future:: a 7-year update of Viagra® (sildenafil citrate) [J].

Jackson, G ;

Gillies, H ;

Osterloh, I .

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 2005, 59 (06) :680-691

[97] Medical progress: Heart failure [J].

Jessup, M ;

Brozena, S .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (20) :2007-2018

[98]

JOHNSON LN, 1994, J NEURO-OPHTHALMOL, V14, P38

[99]

Kallenberg Cees G. M., 1995, Current Opinion in Rheumatology, V7, P568, DOI 10.1097/00002281-199511000-00017

[100] Comparable effects of sildenafil citrate and alprostadil on severe Raynaud's phenomenon in a patient with systemic sclerosis [J].

Kamata, Y ;

Kamimura, T ;

Iwamoto, M ;

Minota, S .

CLINICAL AND EXPERIMENTAL DERMATOLOGY, 2005, 30 (04) :451-451

← 5 6 7 8 9 10 11 12 13 14 →