Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond

被引：423

作者：

Ghofrani, Hossein A.

Osterloh, Ian H.

Grimminger, Friedrich

机构：

[1] Univ Hosp Giessen & Marburg GmbH, Dept Internal Med, Med Clin 2 5, D-35392 Giessen, Germany

[2] Pfizer Ltd, Sandwich CT13 9NJ, Kent, England

来源：

NATURE REVIEWS DRUG DISCOVERY | 2006年 / 5卷 / 08期

关键词：

D O I：

10.1038/nrd2030

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In less than 20 years, the first selective type 5 phosphodiesterase inhibitor, sildenafil, has evolved from a potential anti-angina drug to an on-demand oral treatment for erectile dysfunction ( Viagra), and more recently to a new orally active treatment for pulmonary hypertension (Revatio). Here we describe the key milestones in the development of sildenafil for these diverse medical conditions, discuss the advances in science and clinical medicine that have accompanied this journey and consider possible future indications for this versatile drug.

引用

收藏

页码：689 / 702

页数：14

相关论文

共 201 条

[41] SURVIVAL IN PATIENTS WITH PRIMARY PULMONARY-HYPERTENSION - RESULTS FROM A NATIONAL PROSPECTIVE REGISTRY [J].

DALONZO, GE ;

BARST, RJ ;

AYRES, SM ;

BERGOFSKY, EH ;

BRUNDAGE, BH ;

DETRE, KM ;

FISHMAN, AP ;

GOLDRING, RM ;

GROVES, BM ;

KERNIS, JT ;

LEVY, PS ;

PIETRA, GG ;

REID, LM ;

REEVES, JT ;

RICH, S ;

VREIM, CE ;

WILLIAMS, GW ;

WU, M .

ANNALS OF INTERNAL MEDICINE, 1991, 115 (05) :343-349

[42] Efficacy and safety of sildenafil citrate in men with erectile dysfunction and stable coronary artery disease [J].

DeBusk, RF ;

Pepine, CJ ;

Glasser, DB ;

Shpilsky, A ;

DeRiesthal, H ;

Sweeney, M .

AMERICAN JOURNAL OF CARDIOLOGY, 2004, 93 (02) :147-153

[43] Efficacy and safety of oral sildenafil (Viagra) in men with erectile dysfunction caused spinal cord injury [J].

Derry, FA ;

Dinsmore, WW ;

Fraser, M ;

Gardner, BP ;

Glass, CA ;

Maytom, MC ;

Smith, MD .

NEUROLOGY, 1998, 51 (06) :1629-1633

[44] Acute and prolonged effects of sildenafil on brachial artery flow-mediated dilatation in type 2 diabetes [J].

Desouza, C ;

Parulkar, A ;

Lumpkin, D ;

Akers, D ;

Fonseca, VA .

DIABETES CARE, 2002, 25 (08) :1336-1339

[45] Sildenafil citrate (Viagra) in erectile dysfunction: Near normalization in men with broad-spectrum erectile dysfunction compared with age-matched healthy control subjects [J].

Dinsmore, WW ;

Hodges, M ;

Hargreaves, C ;

Osterloh, IH ;

Smith, MD ;

Rosen, RC .

UROLOGY, 1999, 53 (04) :800-805

[46] Cyclic-3′,5′-nucleotide phosphodiesterase isozymes in cell biology and pathophysiology of the kidney [J].

Dousa, TP .

KIDNEY INTERNATIONAL, 1999, 55 (01) :29-62

[47] Onset and duration of action of sildenafil citrate for the treatment of erectile dysfunction [J].

Eardley, I ;

Ellis, P ;

Boolell, M ;

Wulff, M .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2002, 53 :61S-65S

[48]

Egan R, 2000, ARCH OPHTHALMOL-CHIC, V118, P291

[49] Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A [J].

Fawcett, L ;

Baxendale, R ;

Stacey, P ;

McGrouther, C ;

Harrow, I ;

Soderling, S ;

Hetman, J ;

Beavo, JA ;

Phillips, SC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (07) :3702-3707

[50] Expression of an active, monomeric catalytic domain of the cGMP-binding cGMP-specific phosphodiesterase (PDE5) [J].

Fink, TL ;

Francis, SH ;

Beasley, A ;

Grimes, KA ;

Corbin, JD .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (49) :34613-34620

← 1 2 3 4 5 6 7 8 9 10 →