Imaging and Nanomedicine in Inflammatory Atherosclerosis

被引：143

作者：

Mulder, Willem J. M. ^{[1
,2
]}

Jaffer, Farouc A. ^{[3
,4
,5
]}

Fayad, Zahi A. ^{[1
]}

Nahrendorf, Matthias ^{[5
,6
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dept Radiol, Translat & Mol Imaging Inst, New York, NY 10029 USA

[2] Univ Amsterdam, Acad Med Ctr, Dept Vasc Med, NL-1105 AZ Amsterdam, Netherlands

[3] Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA

[4] Massachusetts Gen Hosp, Div Cardiol, Boston, MA 02114 USA

[5] Harvard Univ, Sch Med, Boston, MA 02114 USA

[6] Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2014年 / 6卷 / 239期

基金：

美国国家卫生研究院;

关键词：

ULTRASMALL SUPERPARAMAGNETIC PARTICLES; TARGETED FUMAGILLIN NANOPARTICLES; CONTRAST-ENHANCED MRI; IRON-OXIDE; PLAQUE INFLAMMATION; MYOCARDIAL-INFARCTION; HIGH-RISK; MACROPHAGES; THERAPY; EFFICACY;

D O I：

10.1126/scitranslmed.3005101

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Bioengineering provides unique opportunities to better understand and manage atherosclerotic disease. The field is entering a new era that merges the latest biological insights into inflammatory disease processes with targeted imaging and nanomedicine. Preclinical cardiovascular molecular imaging allows the in vivo study of targeted nanotherapeutics specifically directed toward immune system components that drive atherosclerotic plaque development and complication. The first multicenter trials highlight the potential contribution of multimodality imaging to more efficient drug development. This review describes how the integration of engineering, nanotechnology, and cardiovascular immunology may yield precision diagnostics and efficient therapeutics for atherosclerosis and its ischemic complications.

引用

页数：11

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