Multiple interlinked mechanisms to circumvent DNA replication roadblocks

被引：15

作者：

Eppink, Berina

Wyman, Claire

Kanaar, Roland

机构：

[1] Erasmus Univ, Med Ctr, Dept Cell Biol & Genet, NL-3000 DR Rotterdam, Netherlands

[2] Erasmus Univ, Med Ctr, Dept Radiat Oncol, NL-3000 DR Rotterdam, Netherlands

来源：

EXPERIMENTAL CELL RESEARCH | 2006年 / 312卷 / 14期

关键词：

homologous recombination; DNA lesion; DNA replication; translesion DNA synthesis; D-loop; genome integrity; replication restart;

D O I：

10.1016/j.yexcr.2006.06.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

DNA replication is a fragile process, since unavoidable lesions in the template DNA cause replicative polymerases to stall, posing a serious threat to genome integrity. Homologous recombination, translesion DNA synthesis and de novo reinitiation of DNA synthesis ensure robust replication by navigating it passed damaged DNA. In this review, we highlight the relationship between these three processes. (c) 2006 Elsevier Inc. All rights reserved.

引用

收藏

页码：2660 / 2665

页数：6

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