Chemical constituents of the aerial part of Celastrus hypoleucus

Fourteen compounds including eight triterpenoids, 12-oleanaen-3beta-ol (beta-amyrin) (1), 12-oleanaen-3beta-caffeate (2), 9(11),12-oleanadien-3beta-ol (3), 9(11),12-oleanadien-3-one (4), 9(11),12-oleanadien-3beta-caffeate (5), friedela-3-one (friedelin) (6), friedela-3-one-29-ol (7), and 12-gammateraen-3beta-ol (tetrehymanol) (8); one steroid, beta-sitosterol (9); one long-chain acid, octadecadienoic acid (10); two esters, ester of n-octaolecyl-4-hydroxy-cinnamate (11), and ester of n-octadecyl-caffeic acid (12); one diterpene, 8beta,19-dihydroxy-3-oxopimar- 15-ene (13); one sesquiterpene, 1beta,2beta,9alpha-trihydroxy-beta-dihydroagarofuran (14) were isolated from the aerial part of Celastrus hypoleucus, These compounds were characterized and identified by physical and spectral methods. All compounds were isolated for the first time from this plant. Among them 12-oleanaen-3beta- caffeate (2) and 9(11),12-oleanadien-3beta-caffeate (5) are two new compounds, and ester of n-octadecyl-caffeic acid (12) possessed antilipoperoxidative effect by specifically scavenging the hydroxyl free radical (.OH) in vitro.