Antioxidant status in experimental hyperthyrodism: Effect of vitamin E supplementation

被引：55

作者：

Seven, A

Seymen, O

Hatemi, S

Hatemi, H

Yigit, G

Candan, G

机构：

[1] UNIV ISTANBUL,CERRAHPASA MED FAC,DEPT BIOCHEM,ISTANBUL,TURKEY

[2] UNIV ISTANBUL,CERRAHPASA MED FAC,DEPT PHYSIOL,ISTANBUL,TURKEY

[3] UNIV ISTANBUL,CERRAHPASA MED FAC,DEPT PEDIATRY,ISTANBUL,TURKEY

[4] UNIV ISTANBUL,CERRAHPASA MED FAC,DEPT INTERNAL MED,ISTANBUL,TURKEY

来源：

CLINICA CHIMICA ACTA | 1996年 / 256卷 / 01期

关键词：

hyperthyroidism; vitamin E; glutathione; glutathione peroxidase; superoxide dismutase;

D O I：

10.1016/S0009-8981(96)06415-7

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Free radical-mediated oxidative stress has been implicated in the genesis and exacerbation of degenerative diseases. In view of the role of oxidative processes in hyperthyroidism, in this study, we investigated the antioxidant status of erythrocytes in experimental hyperthyroidism and the effect of vitamin E supplementation on defense systems. Our findings of significantly increased T-4 and T-3 and undetectable TSH values in thyroxine administered rats confirmed the establishment of hyperthyroidism. Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and glutathione (GSH) values were found to be significantly increased in hyperthyroid rats in comparison to the control group. Vitamin E supplementation to hyperthyroid rats induced a significant decrease in GSH-Px activity and a significant increase in GSH level. These findings show that hyperthyroidism increases the components of the antioxidant system in the erythrocytes. Furthermore, vitamin E supplementation reduces the burden of oxidative stress in hyperthyroidism.

引用

页码：65 / 74

页数：10

共 22 条

[11] ANTIOXIDANT ENZYMES IN HYPERCHOLESTEROLEMIA AND EFFECTS OF VITAMIN-E IN RABBITS [J].