Plasmid-mediated imipenem-hydrolyzing enzyme KPC-2 among multiple carbapenem-resistant Escherichia coli clones in Israel

被引：139

作者：

Navon-Venezia, Shiri

Chmelnitsky, Inna

Leavitt, Azita

Schwaber, Mitchell J.

Schwartz, David

Carmeli, Yehuda

机构：

[1] Tel Aviv Univ, Sackler Fac Med, Div Epidemiol, Tel Aviv Sourasky Med Ctr, IL-64239 Tel Aviv, Israel

[2] Tel Aviv Univ, Sackler Fac Med, Lab Mol Epidemiol & Antiobiot Res, Tel Aviv Sourasky Med Ctr, IL-64239 Tel Aviv, Israel

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 09期

关键词：

D O I：

10.1128/AAC.00438-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Carbapenem resistance in Escherichia coli is rare. We report four genetically unrelated carbapenem-resistant E. coli isolates cultured from four patients hospitalized in Tel Aviv Medical Center. PCR, sequencing, and Southern blot analysis identified KPC-2 as the imipenem-hydrolyzing enzyme in all four strains, carried on different plasmids with a possible common origin. This is the first discovery of KPC-2 in E. coli and the first report of this enzyme originating outside the United States.

引用

页码：3098 / 3101

页数：4

共 21 条

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