New spermine and spermidine derivatives as potent inhibitors of Trypanosoma cruzi trypanothione reductase

被引:45
作者
Bonnet, B [1 ]
Soullez, D [1 ]
DavioudCharvet, E [1 ]
Landry, V [1 ]
Horvath, D [1 ]
Sergheraert, C [1 ]
机构
[1] INST PASTEUR,FAC PHARM,LAB CHIM BIOMOL,CNRS,URA 1309,F-59019 LILLE,FRANCE
关键词
D O I
10.1016/S0968-0896(97)00070-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Several spermine and spermidine derivatives containing 2-amino diphenylsulfide substituents were prepared and tested for their inhibiting effects on Trypanosoma cnizi trypanothione reductase. IC50 values were assessed between 0.3 and 3 mu M. Compound 32 (K-i = 0.4 mu M) is the most potent TR inhibitor described so far. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码:1249 / 1256
页数:8
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