Synthesis and cytotoxic activity of pyridazino[1′,6′:1,2] pyrido[3,4-b]indol-5-inium derivatives as anti-cancer agents

被引：9

作者：

Fontana, A

Benito, EJ

Martín, MJ

Sánchez, N

Alajarín, R

Vaquero, JJ

Alvarez-Builla, J ^{[1
]}

Lambel-Giraudet, S

Leonce, S

Pierré, A

Caignard, D

机构：

[1] Univ Alcala De Henares, Dept Quim Organ, E-28871 Alcala De Henares, Madrid, Spain

[2] Inst Rech Servier, F-92450 Suresnes, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 18期

关键词：

D O I：

10.1016/S0960-894X(02)00472-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several new pyridazino[1',6':1,2]pyrido[3,4-b]indol-5-inium derivatives were synthesised from beta-carboline derivatives and their cytotoxic activity and effect on the cell cycle were evaluated against L1210 cancer cells. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：2611 / 2614

页数：4

共 21 条

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[2]

Foye W.O., 1995, Cancer Chemotherapeutic Agents

[3] INHIBITORS OF MONOAMINE OXIDASE .6. EFFECTS OF SUBSTITUTION ON INHIBITORY ACTIVITY OF 6 (OR 8)-SUBSTITUTED BETA-CARBOLINES [J].